The toxic impact of local anaesthetics in menopausal women: causes, prevention and treatment after local anaesthetic overdose. Local anaesthetic systemic toxicity syndrome

Przegla̜d menopauzalny = Menopause review
Bogusław SobolewskiPiotr Woźniak

Abstract

Gynaecologists often use local anaesthetics in their medical practice. Some concomitant diseases during the menopausal period may cause problems during the qualification of postmenopausal women for general anaesthesia in gynaecological surgery. Many authors suggest the application of local analgesia for particular kinds of gynaecological surgery procedures performed on postmenopausal women, taking into consideration health determinants. While applying local anaesthetics, the possibility of their overdose has to be taken into account. Generalised toxic symptoms which appeared after the local anaesthesia are rare, but potentially are lethal complications. Toxic symptoms after local anaesthetic administration are manifested after accidental administration of a medicine into a blood vessel, when extravascular administration of a large volume of a local anaesthetic is absorbed into a bloodstream or with the reproducible doses of local anaesthetics which are administered when metabolism does not work sufficiently and cannot eliminate these substances. Clinical overdose of local anaesthetics is manifested by disorders in two systems. Firstly, the pathological symptoms come from the central nervous system (CNS). In the second phase, th...Continue Reading

Citations

Dec 19, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Parameswaran AnantanarayananNamasivayam Elavazhagan
Jun 25, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Pooja RameshPrabath Suraweera

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