PMID: 15244185Jul 13, 2004Paper

The toxicity rates of two different regimens of irinotecan

Hepato-gastroenterology
Serdar KaçarAdam Uslu

Abstract

The role of chemotherapy in the management of advanced colorectal cancer has been well established. Although fluorouracil has been the main cytotoxic agent used for colorectal cancer, newer drugs have been developed with promising results. In this study, we compared two different doses of irinotecan combined with 5-fluorouracil/leucoverin (5-FU/LV) in terms of progression-free and overall survival time and toxicity in the patients with recurrent or metastatic colorectal cancer. Patients were divided into groups. The first group received 350 mg/m2 irinotecan every three weeks. The second group was treated by 150 mg/m2 once a week for consecutive four weeks followed by a two-week drug-free interval. All the patients received 500 mg/m2 5-fluorouracil and 20 mg/m2 leucoverin every time they were treated with irinotecan. Median progression-free survival time was found to be 7 +/- 1 and 6 +/- 1 months in the first and seconds groups, respectively. Median overall survival time was found to be 19 +/- 4 and 12 +/- 4 months in the first and second groups, respectively. Alopecia grade 3-4 reaction rates were found to be significantly higher in the first group, while hematological grade 3-4 toxicity rates were higher in the second group. A...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.