The toxicological response of Brazilian chrysotile asbestos: a multidose subchronic 90-day inhalation toxicology study with 92-day recovery to assess cellular and pathological response

Inhalation Toxicology
D M BernsteinJ Chevalier

Abstract

Inhalation toxicology studies with chrysotile asbestos have in the past been performed at exceedingly high doses without consideration of fiber number or dimensions. As such, the exposures have exceeded lung overload levels, making quantitative assessment of these studies difficult if not impossible. To assess the cellular and pathological response in the rat lung to a well-characterized aerosol of chrysotile asbestos, a 90-day subchronic inhalation toxicology study was performed using a commercial Brazilian chrysotile (CA 300). The protocol was based on that established by the European Commission for the evaluation of synthetic vitreous fibers. The study was also designed to assess the potential for reversibility of any such changes and to permit association of responses with fiber dose in the lung and the influence of fiber length. Wistar male rats were randomly assigned to an air control group and to 2 CA 300 exposure groups at mean fiber aerosol concentrations of 76 fibers L > 20 microm/cm3 (3413 total fibers/cm3; 536 WHO fibers/cm3) or 207 fibers L > 20 microm/cm3 (8941 total fibers/cm3; 1429 WHO fibers/cm3). The animals were exposed using a flow-past, nose-only exposure system for 5 days/wk, 6 h/day, during 13 consecutive...Continue Reading

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Citations

May 3, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Brooke T MossmanJames C Bonner
Apr 11, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Silke TreumannBennard van Ravenzwaay
Jan 26, 2013·Critical Reviews in Toxicology·David BernsteinAllen Gibbs
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Jul 22, 2014·Environmental Health : a Global Access Science Source·Guillaume BoulangerMarie-Claude Jaurand
Jul 4, 2006·Regulatory Toxicology and Pharmacology : RTP·David M Bernstein, John A Hoskins
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Aug 18, 2009·Inhalation Toxicology·Yasuo MorimotoIsamu Tanaka
May 9, 2014·Current Opinion in Pulmonary Medicine·David M Bernstein
Aug 7, 2021·Environmental Analysis, Health and Toxicology·Jeong Hee HanCheol Hong Lim

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