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The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses

The Journal of Experimental Medicine

Jan 22, 2020

Longfei ChenChristopher A Hunter

Abstract

The ability of Toxoplasma gondii to inject the rhoptry kinase ROP16 into host cells results in the activation of the transcription factors STAT3 and STAT6, but it is unclear how these events impact infection. Here, parasites that inject Cre-recombinase with rhoptry proteins were used to...read more

Mentioned in this Paper

Macrophage
Rop16 protein, Toxoplasma gondii
Parasites
STAT3
In Vivo
STAT6 protein, human
Antimicrobial Activity
Profile (Lab Procedure)
Protein KINASE
Toxoplasma gondii
62
4
4
Paper Details
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The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses

The Journal of Experimental Medicine

Jan 22, 2020

Longfei ChenChristopher A Hunter

PMID: 31961916

DOI: 10.1084/jem.20181757

Abstract

The ability of Toxoplasma gondii to inject the rhoptry kinase ROP16 into host cells results in the activation of the transcription factors STAT3 and STAT6, but it is unclear how these events impact infection. Here, parasites that inject Cre-recombinase with rhoptry proteins were used to...read more

Mentioned in this Paper

Macrophage
Rop16 protein, Toxoplasma gondii
Parasites
STAT3
In Vivo
STAT6 protein, human
Antimicrobial Activity
Profile (Lab Procedure)
Protein KINASE
Toxoplasma gondii
62
4
4

Similar Papers Found In These Feeds

Virulence Factors

Virulence factors are molecules that are produced by organisms including bacteria, viruses, and fungi. They assist the organism in colonization, dissemination, and enhance the ability to survive in harsh environments and evade the host immune system. Discover the latest research on virulence factors here.

Parasite Genetics

Parasite genetics is the study of the genetic material of parasites. Here is the latest research on parasite genetics.

Related Papers

The Journal of Biological Chemistry

Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6

The Journal of Biological ChemistryJuly 14, 2010
Yi-Ching OngJ C Boothroyd
Paper Details
References
  • References63
  • Citations
12345...
  • References63
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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