The ToxT-dependent methyl-accepting chemoreceptors AcfB and TcpI contribute to Vibrio cholerae intestinal colonization

FEMS Microbiology Letters
Adriana Paola ChaparroK E Klose

Abstract

Vibrio cholerae colonizes the human intestine and causes the acute diarrheal disease cholera. Flagellar-mediated chemotaxis contributes to intestinal colonization as well as infectivity. The virulence-regulatory protein ToxT activates transcription of the genes encoding the major virulence factors cholera toxin and toxin coregulated pilus. ToxT additionally activates transcription of two genes, tcpI and acfB, located within the Vibrio Pathogenicity Island predicted to encode methyl-accepting chemoreceptors. We show that disruption of either tcpI or acfB individually does not noticeably affect V. cholerae intestinal colonization within the infant mouse, but disruption of both tcpI and acfB leads to a decrease in intestinal colonization. These results suggest that TcpI and AcfB may have overlapping or redundant chemotactic functions that contribute to V. cholerae intestinal colonization.

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Citations

Jan 25, 2014·Wiley Interdisciplinary Reviews. RNA·An Ngoc Nguyen, Annick Jacq
Aug 20, 2011·Journal of Medical Microbiology·H Mohammadi-BarzelighiM R Pourshafie
Nov 22, 2013·Gut Microbes·Francesca P Rothenbacher, Jun Zhu
Apr 30, 2020·Molecular Microbiology·Davi R OrtegaAriane Briegel
Jan 10, 2018·Pathogens and Disease·Kenneth M Peterson, Patrick S Gellings
Oct 27, 2017·FEMS Microbiology Reviews·Miguel A Matilla, Tino Krell
Jan 5, 2021·Nihon saikingaku zasshi. Japanese journal of bacteriology·Tatsuro NishikinoMichio Homma
Nov 30, 2021·Microbiology and Immunology·Michio HommaSeiji Kojima

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