The trajectory of gray matter development in Broca's area is abnormal in people who stutter

Frontiers in Human Neuroscience
Deryk S BealLuc F De Nil

Abstract

The acquisition and mastery of speech-motor control requires years of practice spanning the course of development. People who stutter often perform poorly on speech-motor tasks thereby calling into question their ability to establish the stable neural motor programs required for masterful speech-motor control. There is evidence to support the assertion that these neural motor programs are represented in the posterior part of Broca's area, specifically the left pars opercularis. Consequently, various theories of stuttering causation posit that the disorder is related to a breakdown in the formation of the neural motor programs for speech early in development and that this breakdown is maintained throughout life. To date, no study has examined the potential neurodevelopmental signatures of the disorder across pediatric and adult populations. The current study aimed to fill this gap in our knowledge. We hypothesized that the developmental trajectory of cortical thickness in people who stutter would differ across the lifespan in the left pars opercularis relative to a group of control participants. We collected structural magnetic resonance images from 116 males (55 people who stutter) ranging in age from 6 to 48 years old. Differe...Continue Reading

References

Mar 1, 1994·Journal of Computer Assisted Tomography·D L CollinsA C Evans
Jul 11, 1996·Nature·P T FoxJ L Lancaster
Nov 27, 1998·Psychological Review·F H GuentherD Johnson
Oct 9, 1999·Journal of Speech, Language, and Hearing Research : JSLHR·E Yairi, N G Ambrose
Apr 11, 2000·Journal of Speech, Language, and Hearing Research : JSLHR·A Smith, J Kleinow
Apr 11, 2000·Journal of Speech, Language, and Hearing Research : JSLHR·J Kleinow, A Smith
May 29, 2000·Brain : a Journal of Neurology·R SalmelinH J Freund
Apr 20, 2001·Journal of the International Neuropsychological Society : JINS·E R SowellT L Jernigan
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Jan 28, 2003·Journal of Speech, Language, and Hearing Research : JSLHR·Bridget Walsh, Anne Smith
Jan 28, 2003·Nature Neuroscience·Elizabeth R SowellArthur W Toga
Feb 15, 2003·IEEE Transactions on Medical Imaging·Alex P ZijdenbosAlan C Evans
Dec 4, 2003·Journal of Fluency Disorders·Christy L Ludlow, Torrey Loucks
Jan 23, 2004·Nature·Bogdan DraganskiArne May
Jan 30, 2004·Journal of Speech, Language, and Hearing Research : JSLHR·Jordan R GreenKevin J Reilly
Jul 2, 2004·Developmental Psychobiology·Anne Smith, Howard N Zelaznik
Sep 24, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth R SowellArthur W Toga
Sep 29, 2004·Medical Image Analysis·Steven RobbinsSue Whitesides
Dec 14, 2004·BMC Neurology·Lutz JänckeHelmuth Steinmetz
Mar 17, 2005·Journal of Fluency Disorders·Katrin NeumannAnne-Lise Giraud
Oct 26, 2005·Neurology·Sílvia CorberaMaría Angeles Idiazábal
May 16, 2006·Neuroscience Letters·Torrey M J Loucks, Luc F De Nil
May 20, 2006·Journal of Motor Behavior·Torrey M J Loucks, Luc F De Nil
May 30, 2006·NeuroImage·Jason W Bohland, Frank H Guenther
Jun 1, 2006·Journal of Fluency Disorders·Sarah Smits-BandstraJean A Saint-Cyr
Jun 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bogdan DraganskiArne May
Aug 5, 2006·Journal of Communication Disorders·Frank H Guenther
Aug 8, 2006·Journal of Communication Disorders·Torrey M J LoucksJayanthi Sasisekaran
Dec 2, 2006·Brain : a Journal of Neurology·Joseph T Devlin, Kate E Watkins
Jan 30, 2007·Brain and Language·Robert LindenbergRüdiger J Seitz
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·HweeLing LeeCathy J Price
Apr 14, 2007·Nature Reviews. Neuroscience·Gregory Hickok, David Poeppel
Jul 17, 2007·Neuroreport·Deryk S BealLuc F De Nil
Oct 12, 2007·Brain : a Journal of Neurology·Kate E WatkinsPeter Howell
Nov 21, 2007·NeuroImage·Soo-Eun ChangChristy L Ludlow
Nov 24, 2007·NeuroImage·Jason A TourvilleFrank H Guenther
Feb 19, 2008·Journal of Fluency Disorders·Aravind Kumar Namasivayam, Pascal van Lieshout

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Citations

Sep 20, 2016·Frontiers in Human Neuroscience·Anna-Maria MersovLuc De Nil
Apr 22, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P BusanM Sommer
Dec 31, 2016·Human Brain Mapping·Jay DesaiBradley S Peterson
Mar 4, 2017·Developmental Science·Ayoub DaliriSoo-Eun Chang
Dec 12, 2017·Brain : a Journal of Neurology·Nicole E NeefMartin Sommer
Jun 8, 2018·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Rahilsadat HosseiniShouyi Wang
Aug 8, 2018·Brain : a Journal of Neurology·Emily O GarnettSoo-Eun Chang
Jan 6, 2017·Journal of Speech, Language, and Hearing Research : JSLHR·Evan UslerChristine Weber
Aug 25, 2017·Journal of Speech, Language, and Hearing Research : JSLHR·Anne Smith, Christine Weber
Nov 4, 2017·Journal of Speech, Language, and Hearing Research : JSLHR·Kathryn KreidlerChristine Weber
Dec 5, 2019·Frontiers in Human Neuroscience·Ranit SenguptaSazzad M Nasir
Feb 14, 2019·Neurorehabilitation and Neural Repair·Deanna AnderliniWelber Marinovic
Apr 23, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Saul A FrankfordFrank H Guenther
Mar 2, 2018·Journal of Fluency Disorders·Kurt EggersBea R H Van den Bergh
Aug 11, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Eric S JacksonJohn P Spencer

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