The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells

Frontiers in Immunology
Fabienne AndrisOberdan Leo

Abstract

Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differentiation and function, the role played by the proto-oncogene c-Maf remains poorly characterized. We report herein that selective loss of c-Maf expression in the T cell compartment results in defective development of Tfh cells in response to both antigen/adjuvant vaccinations and commensal intestinal bacteria. Accordingly, c-Maf expression in T cells was essential for the development and high-affinity antibody secretion in vaccinated animals. c-Maf was expressed early, concomitantly to BCL6, in Tfh cell precursors and found to regulate Tfh fate in a cell-autonomous fashion. Altogether, our findings reveal a novel, non-redundant, function for c-Maf in the differentiation of Tfh cells and the regulation of humoral immune responses to T-cell-dependent antigens.

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Citations

Mar 23, 2018·Cellular & Molecular Immunology·Hannah M KnochelmannChrystal M Paulos
Apr 24, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·James P HewitsonDimitris Lagos
Aug 21, 2018·Frontiers in Immunology·Sun Jung KimBetty Diamond
Mar 3, 2020·Frontiers in Immunology·Claire ImbrattaGrégory Verdeil
Aug 9, 2020·Journal of Immunology Research·Long-Shan JiYue-Qiu Gao
Jun 27, 2019·Scientific Reports·Tania SinghIsabella Artner
Nov 7, 2019·Journal of Immunology Research·Li WangSong Qin
Nov 10, 2018·Frontiers in Immunology·Haijing WuQianjin Lu
Nov 19, 2020·IScience·Edgar Ruz FernandesDaniela Santoro Rosa
Nov 18, 2020·International Journal of Molecular Sciences·Hannah LawC Mee Ling Munier
Mar 6, 2021·Trends in Immunology·Jinyong Choi, Shane Crotty
Sep 19, 2020·European Journal of Pharmacology·Yaqiong ZhuMeiqun Wang
May 12, 2021·Trends in Immunology·Adesola C OlatundeTracey J Lamb
Sep 10, 2021·Nucleic Acids Research·Xiaojun MaHatice Ulku Osmanbeyoglu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
flow cytometry
Assay

Software Mentioned

FlowJo

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