The transcription factor, Lmx1b, is necessary for the development of the principal trigeminal nucleus-based lemniscal pathway.

Molecular and Cellular Neurosciences
Chuanxi XiangZhou-Feng Chen

Abstract

Little is known of transcriptional mechanisms underlying the development of the trigeminal (V) principal sensory nucleus (PrV), the brainstem nucleus responsible for the development of the whisker-to-barrel cortex pathway. Lmx1b, a LIM homeodomain transcription factor, is expressed in embryonic PrV. In Lmx1b knockout ((-)(/)(-)) mice, V primary afferent projections to PrV are normal, albeit reduced in number, whereas the PrV-thalamic lemniscal pathway is sparse and develops late. Excess cell death occurs in the embryonic Lmx1b(-)(/)(-) PrV, but not in Lmx1b/Bax double null mutants. Expression of Drg11, a downstream transcription factor essential for PrV development and pattern formation, is abolished in PrV, but not in the V ganglion. Consequently, whisker patterns fail to develop in PrV by birth. Rescued PrV cells in Lmx1b/Bax double (-)(/)(-)s failed to rescue whisker-related PrV pattern formation. Thus, Lmx1b and Drg11 may act in the same genetic signaling pathway that is essential for PrV pattern formation.

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Citations

Dec 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Fabien D'AutréauxJean-François Brunet
Nov 8, 2014·International Journal of Molecular Sciences·Shujuan JiangYanyan Zhao
Feb 22, 2012·Progress in Neurobiology·Philippe MorquetteArlette Kolta
Jul 14, 2012·The Journal of Comparative Neurology·Beril G Kivrak, Reha S Erzurumlu
May 4, 2011·Annals of the New York Academy of Sciences·Hong Li, Michael C Crair
May 23, 2012·The European Journal of Neuroscience·Reha S Erzurumlu, Patricia Gaspar
Apr 18, 2014·Somatosensory & Motor Research·Chuanxi XiangMark F Jacquin
Oct 10, 2020·Nature Communications·Sihan ChenZhou-Feng Chen

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