The transcription factor optomotor-blind antagonizes Drosophila haltere growth by repressing decapentaplegic and hedgehog targets

PloS One
Eléanor Simon, I Guerrero

Abstract

In Drosophila, decapentaplegic, which codes for a secreted signaling molecule, is activated by the Hedgehog signaling pathway at the anteroposterior compartment border of the two dorsal primordia; the wing and the haltere imaginal discs. In the wing disc, Decapentaplegic and Hedgehog signaling targets are implicated in cell proliferation and cell survival. However, most of their known targets in the wing disc are not expressed in the haltere disc due to their repression by the Hox gene Ultrabithorax. The T-box gene optomotor-blind escapes this repression in the haltere disc, and therefore is expressed in both the haltere and wing discs. Optomotor-blind is a major player during wing development and its function has been intensely investigated in this tissue, however, its role in haltere development has not been reported so far. Here we show that Optomotor-blind function in the haltere disc differs from that in the wing disc. Unlike its role in the wing, Optomotor-blind does not prevent apoptosis in the haltere but rather limits growth by repressing several Decapentaplegic and Hedgehog targets involved both in wing proliferation and in modulating the spread of morphogens similar to Ultrabithorax function but without disturbing Ul...Continue Reading

References

Jul 31, 1992·Biochemical and Biophysical Research Communications·G O PflugfelderB Poeck
Dec 1, 1991·Genes & Development·J T Wagner-BernholzW J Gehring
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G O PflugfelderM Heisenberg
Nov 1, 1984·Cell·R A White, M Wilcox
Oct 11, 1996·Science·M CallejaG Morata
Jun 19, 2002·Development Genes and Evolution·Thomas Klein
Apr 6, 2004·Developmental Biology·David del Alamo RodríguezFernando J Díaz-Benjumea
Oct 19, 2006·Developmental Biology·Kalpana MakhijaniL S Shashidhara
Oct 20, 2006·Development·Luis F de NavasErnesto Sánchez-Herrero
Sep 15, 2007·Development·Christopher M Walsh, Sean B Carroll
Jan 9, 2010·Development·Jonathan EnriquezAlain Vincent
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Anastasios Pavlopoulos, Michael Akam
Jun 22, 2011·The Biochemical Journal·Jonatan SánchezRosa Barrio
Jan 12, 2016·Epigenetics & Chromatin·Ching Yew BehRobert White

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Citations

Nov 28, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Richard GawneH Frederik Nijhout
May 20, 2017·Current Opinion in Insect Science·Yoshinori Tomoyasu

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis