The transcription factors AP-2β and AP-2α are required for survival of sympathetic progenitors and differentiated sympathetic neurons

Developmental Biology
Mirko SchmidtHermann Rohrer

Abstract

Differentiation of sympathetic neurons is controlled by a group of transcription factors, including Phox2b, Ascl1, Hand2 and Gata3, induced by bone morphogenetic proteins (BMPs) in progenitors located in ganglion primordia at the dorsal aorta. Here, we address the function of the transcription factors AP-2β and AP-2α, expressed in migrating neural crest cells (NCC) and maintained in sympathetic progenitors and differentiated neurons. The elimination of both AP-2α and AP-2β results in the virtually complete absence of sympathetic and sensory ganglia due to apoptotic cell death of migrating NCC. In the AP-2β knockout only sympathetic ganglia (SG) are targeted, leading to a reduction in ganglion size by about 40%, which is also caused by apoptotic death of neural crest progenitors. The conditional double knockout of AP-2α and AP-2β in sympathetic progenitors and differentiated noradrenergic neurons results in a further decrease in neuron number, leading eventually to small sympathetic ganglion rudiments postnatally. The elimination of AP-2β also leads to the complete absence of noradrenergic neurons of the Locus coeruleus (LC). Whereas AP-2α/β transcription factors are in vivo not required for the onset or maintenance of noradrene...Continue Reading

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Citations

Jun 27, 2017·Pigment Cell & Melanoma Research·Hannah E SebergRobert A Cornell
Mar 14, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Erin A BassettJudith A West-Mays
Mar 20, 2015·Developmental Neurobiology·Julia HolzmannHermann Rohrer
Dec 15, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yoko Kameda
Jul 26, 2012·Alcoholism, Clinical and Experimental Research·Kate FreemanJames S Schwaber
Mar 2, 2017·PLoS Genetics·Hannah E SebergRobert A Cornell
Sep 16, 2017·Frontiers in Molecular Neuroscience·Norliyana ZainolabidinAlbert I Chen
Nov 23, 2011·The European Journal of Neuroscience·Hermann Rohrer
Jan 13, 2015·Development, Growth & Differentiation·Rachael Lumb, Quenten Schwarz
Jan 13, 2012·Developmental Biology·Leslie HuberHermann Rohrer

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