The transcription network regulating melanocyte development and melanoma

Pigment Cell Research
Keith W Vance, Colin Goding

Abstract

The enormous variety of pigmentation phenotypes in nature reflects a series of remarkable events that begin in the neural crest and end with the manufacture and distribution of pigment by mature melanocytes located in the epidermis and hair follicles. While the origins of melanoblasts from multipotent precursors in the neural crest is striking in itself, yet more so is the fact that these pioneer melanoblasts manage to undertake and survive their long migration, and in doing so proliferate and maintain their identity before ultimately arriving at their destination and undergoing differentiation. With the application of the powerful combination of genetics and molecular and cell biology the mystery surrounding the genesis of the melanocyte lineage is slowly being unravelled. At its heart is the powerful alliance between signal transduction and transcription that coordinates the program of gene expression that confers on a cell its identity, provides its passport for migration, and instructs it in the arts of survival and timely reproduction. The realization that the proliferation and migration of melanoblasts during development resembles closely the proliferation and metastasis of melanoma, a highly dangerous and increasingly co...Continue Reading

References

Dec 9, 1988·Nucleic Acids Research·P M CoxC R Goding
Aug 1, 1994·Pigment Cell Research·R A SturmP G Parsons
Jan 1, 1994·Human Mutation·C T BaldwinA Milunsky
Jan 1, 1993·Nature Genetics·M TassabehjiT Strachan
Feb 27, 1996·Biochemical and Biophysical Research Communications·N FuseS Shibahara
Jan 13, 1998·Nature Genetics·E M Southard-SmithW J Pavan
Feb 14, 1998·Nature Genetics·V PingaultM Goossens
Mar 21, 1998·Nature Genetics·A WatanabeM Tachibana
Jul 11, 1998·The Journal of Biological Chemistry·E R PriceD E Fisher
Aug 12, 1998·The Journal of Cell Biology·C BertolottoR Ballotti
Dec 1, 1998·Genes & Development·L ChinR A DePinho
Sep 10, 1999·The Journal of Biological Chemistry·M D GalibertC R Goding
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S AdachiY Kitamura
Apr 5, 2000·The Journal of Biological Chemistry·K TakedaS Shibahara
Aug 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·K J DunnW J Pavan
Oct 21, 2000·Pigment Cell Research·S ShibaharaK Takeda
Nov 30, 2000·Melanoma Research·D J Easty, D C Bennett
Mar 7, 2001·Mechanisms of Development·T J HornyakE B Ziff
May 16, 2001·International Review of Cytology·V E Papaioannou
May 31, 2001·The Journal of Biological Chemistry·M FurumuraV J Hearing

❮ Previous
Next ❯

Citations

Dec 7, 2007·Archivum Immunologiae Et Therapiae Experimentalis·Amélie MarquetteNicolas Dumaz
May 13, 2006·Glycoconjugate Journal·Bidisha SahaRanjan Bhadra
Jul 13, 2006·Heredity·D M Parichy
Aug 29, 2007·Oncogene·C MichaloglouD S Peeper
Jan 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andy J ChienRandall T Moon
May 19, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elena V SviderskayaDorothy C Bennett
Dec 22, 2006·Genes & Development·Suzanne CarreiraColin R Goding
Mar 21, 2008·Pigment Cell & Melanoma Research·Tobias Schatton, Markus H Frank
Nov 6, 2008·Pigment Cell & Melanoma Research·Anthony L Cook, Richard A Sturm
Nov 10, 2009·Pigment Cell & Melanoma Research·Aline PrimotMarie-Dominique Galibert
Aug 24, 2010·Pigment Cell & Melanoma Research·Keith S Hoek, Colin R Goding
May 24, 2011·Pigment Cell & Melanoma Research·Ossia M EichhoffKeith S Hoek
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kazuo KoyanagiDave S B Hoon
May 3, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Emi SatoShuji Kojima
Jan 5, 2011·PLoS Genetics·Meera ShahZe'ev A Ronai
Jun 14, 2012·PloS One·Manfred SchartlSvenja Meierjohann
Aug 1, 2012·PloS One·Viviane BaralNadege Bondurand
Feb 1, 2009·Biomarkers in Medicine·Monica NeaguIrina Margaritescu
Jun 20, 2013·International Journal of Biological Sciences·Mingyou LiYunhan Hong
Feb 5, 2010·International Journal of Cell Biology·Hee-Young ParkBarbara A Gilchrest
Mar 28, 2013·Cellular and Molecular Life Sciences : CMLS·Tarik Regad
May 6, 2015·Expert Opinion on Therapeutic Patents·Thanigaimalai PillaiyarSang-Hun Jung
Oct 28, 2015·Expert Review of Clinical Immunology·Francesco MannavolaFranco Silvestris
Aug 29, 2012·The Journal of Cell Biology·Pei-Chih LeeCarole LaBonne
Jul 17, 2007·Pigment Cell Research·Florence DemayColin R Goding
Oct 6, 2009·Biochemical and Biophysical Research Communications·Munju ChoSangtaek Oh
May 26, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Robert S de WijnChantal M A M van der Horst
Jul 18, 2008·The Journal of Investigative Dermatology·Barbara DessarsPierre Heimann
Apr 27, 2007·The Journal of Investigative Dermatology·Richard A NewtonRichard A Sturm
Feb 14, 2006·The Journal of Investigative Dermatology·Sébastien CorreMarie-Dominique Galibert
Aug 30, 2008·The Journal of Investigative Dermatology·Glen M BoylePeter G Parsons
Oct 31, 2008·The Journal of Investigative Dermatology·Feng LiuFrank L Meyskens

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.