The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue

The Journal of Endocrinology
Scott M MacKenzieEleanor Davies

Abstract

Steroid actions on brain tissue have been implicated in processes such as blood pressure regulation and neurodegeneration, including the progression of Alzheimer's disease (AD). mRNAs from all of the genes required for de novo synthesis from cholesterol of aldosterone and corticosterone (equivalent to cortisol in humans) have been identified in rat brain, together with abundant steroid hormone receptors, but the situation in human brain requires clarification. We used real-time RT-PCR to assess whether transcription of 13 steroid-associated genes occurs in human hippocampus and cerebellum, and to identify whether transcription of these genes is significantly altered in cases of AD. Frozen post-mortem samples of hippocampus and cerebellum from patients with AD (n=7) and age-matched controls free from neurological disease at the time of death (n=9) were used. We found all of the genes under investigation to be transcribed within normal and AD hippocampus and cerebellum except for CYP11B1 (11beta-hydroxylase), CYP11B2 (aldosterone synthase) and CYP17 (17alpha-hydroxylase). No significant differences in mRNA levels were observed between the AD tissue and the equivalent control tissue, although significant regional differences in ge...Continue Reading

Citations

May 16, 2009·Current Hypertension Reports·Frances McManusE Marie Freel
Mar 6, 2009·American Journal of Physiology. Renal Physiology·Joel C Geerling, Arthur D Loewy
Aug 10, 2011·Journal of Psychiatric Research·Leonardo BaldaçaraRodrigo A Bressan
Apr 16, 2008·Clinical Endocrinology·Scott M MacKenzieEleanor Davies
Nov 1, 2016·Balsaeng'gwa saengsig·Hye Rim Byeon, Sung-Ho Lee
Sep 6, 2018·Food & Function·Carine Smith, Amanda Swart
May 19, 2019·Journal of Neuroendocrinology·Silvia GiattiRoberto Cosimo Melcangi
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May 21, 2021·Frontiers in Neuroendocrinology·Yiqi Christina Lin, Vassilios Papadopoulos
Jul 20, 2011·Molecular and Cellular Endocrinology·Scott M MacKenzieEleanor Davies

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