The transcriptional and epigenomic foundations of ground state pluripotency

Hendrik MarksHendrik G Stunnenberg


Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as "2i" postulated to establish a naive ground state. We show that the transcriptome and epigenome profiles of serum- and 2i-grown ES cells are distinct. 2i-treated cells exhibit lower expression of lineage-affiliated genes, reduced prevalence at promoters of the repressive histone modification H3K27me3, and fewer bivalent domains, which are thought to mark genes poised for either up- or downregulation. Nonetheless, serum- and 2i-grown ES cells have similar differentiation potential. Precocious transcription of developmental genes in 2i is restrained by RNA polymerase II promoter-proximal pausing. These findings suggest that transcriptional potentiation and a permissive chromatin context characterize the ground state and that exit from it may not require a metastable intermediate or multilineage priming.


Jan 11, 1996·Nature·G D PennyNeil Brockdorff
Mar 15, 1997·Genes & Development·M HuTariq Enver
Sep 11, 2002·Trends in Cell Biology·Tom BurdonPierre Savatier
Jan 14, 2003·Nature Biotechnology·Qi-Long YingAustin Smith
May 30, 2003·Nature·Kazutoshi TakahashiShinya Yamanaka
Sep 21, 2004·Oncogene·Ian Chambers, Austin Smith
Feb 8, 2006·Nature Cell Biology·Keisuke KajiBrian Hendrich
Mar 30, 2006·Nature Cell Biology·Véronique AzuaraAmanda G Fisher
Jun 13, 2006·Nature·Natalia IvanovaIhor R Lemischka
Feb 26, 2008·Cell·Eszter Posfai
May 9, 2008·Cell Stem Cell·Sol EfroniEran Meshorer
Nov 6, 2008·Cell Stem Cell·Thomas Graf, Matthias Stadtfeld
Nov 11, 2008·Development·Akira Nakamura, Geraldine Seydoux
Jun 6, 2009·Nature Medicine·Jennifer NicholsAnne Cooke
Jul 8, 2009·Genome Research·Hendrik MarksHendrik G Stunnenberg
Jul 25, 2009·Science·Alistair N Boettiger, Michael Levine
Sep 18, 2009·Developmental Cell·Robert C AkkersGert Jan C Veenstra
Feb 4, 2010·Genes & Development·Martin LeebAnton Wutz
Apr 8, 2010·EMBO Molecular Medicine·Austin Smith
May 4, 2010·Cell·Peter B RahlRichard A Young
May 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jacob H HannaRudolf Jaenisch
Jul 28, 2010·Biochemical Society Transactions·Jason WrayAustin Smith
Sep 4, 2010·Cell·Jung-Shin LeeAli Shilatifard
Dec 25, 2010·Nature Structural & Molecular Biology·Ziyang MaJoanna Wysocka
Mar 19, 2011·Cell·Richard A Young
Apr 9, 2011·Cell Stem Cell·Kyle M Loh, Bing Lim
May 10, 2011·Molecular Cell·Frank W SchmitgesNicolas H Thomä
Oct 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Wei WangPentao Liu


Oct 12, 2012·Cellular and Molecular Life Sciences : CMLS·Tatsuya Ohhata, Anton Wutz
Sep 21, 2013·Stem Cell Reports·Harry G LeitchAustin Smith
May 21, 2013·Trends in Cell Biology·Maaike Welling, Niels Geijsen
Jun 4, 2013·Acta Pharmacologica Sinica·Jian-bin SuBaoming Qin
Dec 12, 2012·Cell Research·Jia-Chi Yeo, Huck-Hui Ng
Oct 25, 2013·Nature·Effie Apostolou, Konrad Hochedlinger
May 16, 2013·Nature Reviews. Molecular Cell Biology·Patrick Cahan, George Q Daley
Feb 19, 2013·Nature Structural & Molecular Biology·Harry G LeitchPetra Hajkova
Mar 7, 2013·Nature Structural & Molecular Biology·Christoph Bock, Anton Wutz
Oct 1, 2013·Nature Structural & Molecular Biology·Chen DavidovichThomas R Cech
Oct 22, 2013·Nature Structural & Molecular Biology·Syuzo KanekoRoberto Bonasio
Dec 18, 2013·Biologie aujourd'hui·Pierluigi Scerbo, Laurent Coen
Nov 21, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Akira WatanabeShinya Yamanaka
Jun 22, 2013·Genes & Development·Philipp VoigtDanny Reinberg
Oct 10, 2012·Molecular and Cellular Biology·Olga I KulaevaVasily M Studitsky
Dec 7, 2013·Epigenetics & Chromatin·Martin Leeb, Anton Wutz
Aug 23, 2012·Development·Martin LeebAnton Wutz
Oct 9, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Christoffer TammJin-Ping Li
Jan 18, 2013·PloS One·Colin T MaguireMaureen L Condic
Oct 8, 2013·PloS One·Guangzhen JiLin Liu
Dec 18, 2013·PloS One·Christoffer TammCecilia Annerén
Mar 20, 2014·PloS One·Maria HerbergIngo Roeder
Jan 28, 2014·Nature·Maria A ChristophorouTony Kouzarides
Dec 25, 2013·Nature Reviews. Genetics·Taiping Chen, Sharon Y R Dent
Oct 31, 2013·Briefings in Functional Genomics·L Carine Stapel, Nadine L Vastenhouw
Jun 14, 2013·Reproduction, Fertility, and Development·Joy RathjenDavid K Gardner
Apr 22, 2014·Nature Materials·Stefano PagliaraK J Chalut
May 9, 2014·Trends in Biochemical Sciences·Fumio Nakaki, Mitinori Saitou
Jul 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sen WuMario R Capecchi
Apr 18, 2014·Stem Cells and Development·Anne-Clémence VeillardAlice Jouneau
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Anton Wutz
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Graziano Martello, Austin Smith
Jul 6, 2013·Cell Stem Cell·Austin Smith
Sep 10, 2014·Nature Reviews. Genetics·Hua YanDanny Reinberg
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tüzer Kalkan, Austin Smith
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sophie M Morgani, Joshua M Brickman
May 31, 2014·Tissue Engineering. Part B, Reviews·Yoon JeongKwan Hyi Lee
Feb 19, 2016·Genome Biology·Tomislav IlicicSarah A Teichmann
Feb 13, 2016·Cell·Roberta ScognamiglioAndreas Trumpp
Jan 1, 2014·Journal of Clinical Medicine·Tetsuya Ishii
Oct 4, 2014·Cell Stem Cell·Jamie A Hackett, M Azim Surani
Feb 11, 2016·Nature Reviews. Molecular Cell Biology·Leehee WeinbergerJacob H Hanna
Jan 26, 2016·Cell Reports·Lauren E SurfaceLaurie A Boyer
Jan 28, 2016·Nature·Maud de DieuleveultMatthieu Gérard
Nov 12, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Adam Scheidegger, Sergei Nechaev
Oct 28, 2015·Proceedings of the National Academy of Sciences of the United States of America·Pierre J FabreDenis Duboule
Feb 18, 2016·Nature Reviews. Molecular Cell Biology·Zachary D SmithAlexander Meissner
Jan 29, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Pavel SimaraDan S Kaufman
Jan 15, 2016·Nucleic Acids Research·Shilpa S DharMin Gyu Lee
Aug 26, 2015·Stem Cells·Chen-Yun ChenPatrick C H Hsieh
Dec 30, 2015·Stem Cell Reports·Maria Gomes FernandesSusana M Chuva de Sousa Lopes
Dec 22, 2015·Trends in Immunology·Kathryn J WoodJoanna Hester
Sep 10, 2014·Genesis : the Journal of Genetics and Development·Zhaoyu LinJing Zhao
Jan 23, 2016·Stem Cells International·Luca FagnocchiAlessio Zippo
Jan 23, 2016·Stem Cells International·Antonio Romito, Gilda Cobellis
Nov 6, 2015·Current Opinion in Cell Biology·Vincent Pasque, Kathrin Plath
Dec 17, 2015·Scientific Reports·Sara TaleahmadGhasem Hosseini Salekdeh
Jul 18, 2015·Seminars in Cell & Developmental Biology·Néstor SaizAnna-Katerina Hadjantonakis
Nov 28, 2015·Stem Cell Reports·Kristen J BrennandRudolf Jaenisch
Jan 16, 2016·Stem Cells International·Clair E WeidgangMartin Mueller
Aug 21, 2015·Current Opinion in Genetics & Development·Yair S ManorJacob H Hanna
Jun 15, 2013·Stem Cells·Julie MathieuHannele Ruohola-Baker
Dec 2, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Sascha Duttke
Oct 3, 2015·Cell Stem Cell·Aleksandra A KolodziejczykSarah A Teichmann
Oct 3, 2015·Cell Stem Cell·Ishan Kumar, Natalia Ivanova
Sep 3, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Olivia Padovan-Merhar, Arjun Raj
Jan 3, 2013·Development, Growth & Differentiation·Christian JeanBertrand Pain
Mar 22, 2016·Cell Stem Cell·Hui ZhangYali Dou
Oct 16, 2015·The Journal of Cell Biology·Sujash S ChatterjeeRamanuj DasGupta
May 1, 2015·Cell Cycle·Mehdi PirouzMichael Kessel
Sep 30, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·George Q Daley
Oct 30, 2014·The FEBS Journal·Jason Signolet, Brian Hendrich
Jan 22, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Maria HerbergIngo Roeder
Sep 25, 2014·The FEBS Journal·Jessica SegalésPura Muñoz-Cánoves
May 28, 2014·Biological Reviews of the Cambridge Philosophical Society·Ewart KuijkEdwin Cuppen
May 20, 2015·The International Journal of Biochemistry & Cell Biology·Ila van KruijsbergenGert Jan C Veenstra
Aug 19, 2015·Genome Biology·Andrea CerasePhilip Avner
Aug 4, 2015·Genome Biology·Hendrik MarksHendrik G Stunnenberg
Sep 13, 2012·Biochimica Et Biophysica Acta·Tobias A BeyerJeffrey L Wrana
May 24, 2013·Biochemical Society Transactions·Kirsten R McEwenPetra Hajkova
Feb 27, 2015·Biomolecular Concepts·Kazuyuki Ohbo, Shin-Ichi Tomizawa
May 7, 2016·Stem Cell Reports·Bryony GrahamMatthias Merkenschlager
May 26, 2015·Trends in Cell Biology·Rachael A NimmoTariq Enver
Dec 5, 2014·Nature·Roshan M KumarJames J Collins
Jun 26, 2015·Scientific Data·Munazah AndrabiNick R Love
Mar 15, 2015·Cell·Maria Aurelia RicciMaria Pia Cosma
Jun 7, 2014·Cell Stem Cell·Jia-Chi YeoHuck-Hui Ng
May 30, 2015·Retrovirology·Luisa Robbez-Masson, Helen M Rowe
Apr 11, 2015·Biochimica Et Biophysica Acta·Sarita S Paranjpe, Gert Jan C Veenstra
Jun 12, 2013·Cell Reports·Sophie M MorganiJoshua M Brickman
Mar 19, 2014·Cell Stem Cell·Ronald J ParchemRobert Blelloch
Jan 18, 2013·Nucleus·Melanie A Eckersley-MaslinDavid L Spector
Jan 15, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Anna PalauMarcus Buschbeck
Aug 10, 2013·Current Biology : CB·Gill May, Tariq Enver
Feb 2, 2013·Mutation Research·Shiqiang Zhang, Yue Teng
Oct 8, 2013·Biochimica Et Biophysica Acta·Hendrik Marks, Hendrik G Stunnenberg
Dec 29, 2013·Stem Cell Reports·Jamie A HackettM Azim Surani
Feb 15, 2014·Stem Cell Reports·Caroline KubaczkaHubert Schorle
May 9, 2012·Cell Stem Cell·Matthew G Guenther, Richard A Young
Mar 29, 2014·Stem Cell Reports·Christina GalonskaAlexander Meissner
Nov 6, 2012·Cell Stem Cell·Clifford D L FolmesAndre Terzic
Mar 19, 2013·Cell·Bernadett Papp, Kathrin Plath
Aug 6, 2013·Cell·Ben D MacArthur, Ihor R Lemischka
Jul 20, 2014·Molecular Cell·Zakary S SingerMichael B Elowitz
Feb 7, 2015·Science·Hendrik G StunnenbergYaser Atlasi
Oct 24, 2014·Annual Review of Entomology·Hua YanDanny Reinberg
Dec 17, 2014·Future Medicinal Chemistry·Catherine BaugéKarim Boumediene
May 7, 2016·Cell Stem Cell·Jonathan A BeaganJennifer E Phillips-Cremins
May 18, 2016·Genome Biology·Diana Guallar, Jianlong Wang
Jun 4, 2016·Cell Stem Cell·Mitinori Saitou, Hidetaka Miyauchi
Mar 24, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Daniela Ávila-GonzálezNéstor Fabián Díaz
Jun 28, 2016·Cell Stem Cell·Miguel FidalgoJianlong Wang
Jun 21, 2016·Cell Stem Cell·Jin ZhangGeorge Q Daley
Jan 23, 2015·PLoS Genetics·Peter J ThompsonMatthew C Lorincz
Jul 26, 2016·Nucleic Acids Research·Natasha K TuanoAssam El-Osta
Jul 29, 2016·Human Molecular Genetics·Haoyu WuLucia Daxinger
Aug 22, 2016·Trends in Genetics : TIG·Harry G LeitchPetra Hajkova
Sep 10, 2016·Cell·Jun WuJuan Carlos Izpisua Belmonte
Oct 11, 2016·Nature Cell Biology·Nicola FestucciaPablo Navarro
Oct 11, 2016·ELife·Robert S IllingworthJoshua M Brickman
Nov 8, 2016·Stem Cells International·Na LiJinlian Hua
Oct 31, 2016·Biochemical and Biophysical Research Communications·Moein FarshchianAhmad Reza Bahrami
Oct 25, 2016·Molecular Cell·Mahmoud-Reza RafieeJeroen Krijgsveld
Nov 5, 2016·Molecular Cell·Shengjiang TuDanny Reinberg
Nov 15, 2016·Nature Genetics·Maxim V C GreenbergDéborah Bourc'his
Feb 4, 2016·PloS One·Daniela TagliaferriGeppino Falco
Jan 4, 2017·Nature Reviews. Genetics·Mo Li, Juan Carlos Izpisua Belmonte
Jan 26, 2017·Journal of Molecular Biology·Maxime BodakConstance Ciaudo
Jul 11, 2014·Biology of Reproduction·Zachariah McLeanBjörn Oback
Jan 16, 2016·Cold Spring Harbor Symposia on Quantitative Biology·Pierre J FabreDenis Duboule
Mar 7, 2017·Current Opinion in Genetics & Development·Mario IurlaroWolf Reik
Jan 22, 2015·Scientific Reports·Mathias ErnstGeorg Fuellen
Jan 20, 2017·The Journal of Cell Biology·Daniel Cirera-SalinasConstance Ciaudo
May 11, 2017·Genes & Development·Kaixiang CaoAli Shilatifard
Apr 20, 2013·Experimental Biology and Medicine·Lourdes SerranoJay Tischfield
Oct 16, 2016·Stem Cells·Agata StryjewskaDanny Huylebroeck
Jun 8, 2017·Stem Cell Reports·Jamie A HackettM Azim Surani
Dec 20, 2017·Nature Genetics·Diego Rodriguez-TerronesMaria-Elena Torres-Padilla
Mar 30, 2018·PloS One·Ilya R AkberdinNikolay A Kolchanov
Oct 17, 2017·Nucleic Acids Research·Sharon SchlesingerEran Meshorer
Jan 24, 2018·Development, Growth & Differentiation·Masaki Kinoshita, Austin Smith
Apr 18, 2018·Nature Cell Biology·Yaser Atlasi, Hendrik G Stunnenberg
Apr 14, 2018·Genes & Development·Cristina Mayor-RuizOscar Fernandez-Capetillo
Nov 24, 2017·Scientific Reports·Walaa F AlsanieClare L Parish
Aug 12, 2016·Genetics & Epigenetics·Jifang XiaoLiangqi Xie
Oct 5, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Steven Blinka, Sridhar Rao
Feb 9, 2017·Development·Tüzer KalkanAustin Smith
Nov 21, 2015·Development·Stoyana AlexandrovaJennifer Nichols
Dec 20, 2017·ELife·Andrea CorsinottiIan Chambers
Jan 8, 2014·Molecular and Cellular Biology·Marianne Terndrup PedersenKristian Helin
Jun 16, 2016·Nature Communications·Luca FagnocchiAlessio Zippo
Nov 28, 2018·Journal of Molecular Cell Biology·Hui SangNa Liu
Oct 21, 2018·Cellular and Molecular Life Sciences : CMLS·Amandine CzajkowskiBrigitte Malgrange
Feb 16, 2019·Epigenetics & Chromatin·René A M DirksHendrik Marks
Feb 28, 2018·Nature Structural & Molecular Biology·Jonas W HøjfeldtKristian Helin
Sep 26, 2017·Nature Cell Biology·Kathryn G V AndersonJoshua M Brickman
Oct 12, 2017·Nature·Jian YangPentao Liu
Apr 6, 2019·Expert Review of Proteomics·Cristina SayagoJavier Muñoz
Jul 24, 2015·Nature Reviews. Molecular Cell Biology·Chiara MozzettaSlimane Ait-Si-Ali
May 1, 2019·Nature Cell Biology·Yaser AtlasiHendrik G Stunnenberg
Sep 25, 2015·Nature·Alejandro De Los AngelesGeorge Q Daley
Aug 15, 2017·Nature Reviews. Genetics·Yaser Atlasi, Hendrik G Stunnenberg
Jun 5, 2019·Nature Reviews. Genetics·Xiao Li, Xiang-Dong Fu
May 28, 2019·Genes & Development·Leighton Core, Karen Adelman
Jan 31, 2018·Molecular Systems Biology·Ayako Yachie-KinoshitaPeter W Zandstra
Dec 18, 2015·The EMBO Journal·Gillian MorrisonAustin Smith
Jun 17, 2015·EMBO Reports·Maaike WellingNiels Geijsen
Feb 21, 2018·BMC Developmental Biology·Anna MantsokiAnagha Joshi
Dec 19, 2019·EMBO Reports·Diego Rodriguez-TerronesMaria-Elena Torres-Padilla
Nov 17, 2019·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hiroaki OhishiHiroyuki Sasaki
Jan 24, 2020·Current Protocols in Stem Cell Biology·Jan J Zylicz
Feb 19, 2020·Cell Biology International·Divya DesaiPrasad Pethe
Aug 19, 2017·Biology of Sex Differences·Rachael J WernerNora Engel
Oct 2, 2019·Nature Communications·Sudhir ThakurelaAlexander Meissner
Sep 30, 2020·Cell Proliferation·Jing HaoYangming Wang
Dec 7, 2016·Frontiers in Cell and Developmental Biology·Vimal K SinghRamesh Chandra
Aug 12, 2017·Epigenomics·Ekaterina V NizovtsevaVasily M Studitsky
Aug 29, 2017·Current Stem Cell Reports·Hanna L Sladitschek, Pierre A Neveu
Jul 15, 2017·Epigenetics & Chromatin·Kevin T EbataMiguel Ramalho-Santos
May 23, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R Abu-DawudJ Adjaye
Sep 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Razi GreenfieldHoward Cedar
Aug 21, 2019·Frontiers in Cell and Developmental Biology·Camila Felix de Lima FernandesMarilene Hohmuth Lopes
Apr 3, 2020·Nature Communications·Yaser AtlasiHendrik G Stunnenberg
Jun 24, 2020·Nature Structural & Molecular Biology·Kristjan H Gretarsson, Jamie A Hackett
Dec 30, 2014·Physiological Reviews·Kyle M LohLay Teng Ang
Feb 22, 2017·Frontiers in Cell and Developmental Biology·Luca Fagnocchi, Alessio Zippo
Jun 15, 2017·BMC Developmental Biology·Sophie MorganiAnna-Katerina Hadjantonakis
Sep 19, 2018·Scientific Reports·J L Caldu-PrimoJ Davila-Velderrain
Dec 5, 2018·Nature Communications·Derrick C WanKevin C Wang
Jul 30, 2019·Frontiers in Physiology·Rachel A ShparbergMichael B Morris
Mar 8, 2020·Nature Communications·Atsuya NishiyamaMakoto Nakanashi
Mar 18, 2020·Science Advances·Helena G AsenjoDavid Landeira
May 20, 2020·In Vitro Cellular & Developmental Biology. Animal·Qiaoyu ChenRongfeng Li
Feb 1, 2015·Reproduction, Fertility, and Development·Pablo Juan Ross, Sebastian Canovas
May 26, 2017·Stem Cells and Development·Ludovic ZimmerlinElias T Zambidis
Jan 13, 2018·Nature Structural & Molecular Biology·Courtney W HannaGavin Kelsey
Jul 6, 2018·Frontiers in Cell and Developmental Biology·Lamuk Zaveri, Jyotsna Dhawan
Sep 5, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Masaki YagiYasuhiro Yamada
Nov 14, 2018·Cellular and Molecular Life Sciences : CMLS·Seyedeh-Nafiseh HassaniHossein Baharvand
Sep 11, 2019·Annual Review of Genetics·Elizabeth M Duncan, Alejandro Sánchez Alvarado
Nov 2, 2019·Briefings in Functional Genomics·Tomas PachanoAlvaro Rada-Iglesias
Sep 4, 2020·International Journal of Molecular Sciences·Giuseppina DivisatoSilvia Parisi
Feb 3, 2015·Current Protocols in Stem Cell Biology·Raman V NelakantiJoseph C Wu
Jun 27, 2017·NPJ Systems Biology and Applications·Etsuo A SusakiHiroki R Ueda
May 29, 2018·Nature Genetics·Matteo PerinoGert Jan C Veenstra
Oct 6, 2020·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Tiffany A GarbuttDavid W Threadgill
Oct 14, 2020·Stem Cell Reviews and Reports·Vladimir V SherstyukSuren M Zakian
Oct 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kaixiang CaoAli Shilatifard
Nov 26, 2020·Nature Communications·Christopher B MulhollandHeinrich Leonhardt
Jun 13, 2019·Cell Reports·Shen-Hsi YangAndrew D Sharrocks
Aug 11, 2020·Experimental Cell Research·Cian J LynchManuel Serrano
Sep 16, 2020·Cold Spring Harbor Perspectives in Biology·Patrick S L Lim, Eran Meshorer
Dec 31, 2020·Life Science Alliance·Li DingFrank Buchholz
Jan 13, 2021·The EMBO Journal·Damian DalcherRaffaella Santoro
Oct 30, 2020·Nature Communications·Marcel TarbierMarc R Friedländer
Feb 26, 2021·Science Advances·Michela SerresiGaetano Gargiulo
Mar 6, 2021·Veterinary Research·Bertrand Pain
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Li SunAndrew P Hutchins
Mar 27, 2021·Nature Communications·Trisha A Macrae, Miguel Ramalho-Santos
Mar 27, 2021·Nature Communications·Ana Martinez-ValJavier Munoz
Mar 22, 2021·Genomics, Proteomics & Bioinformatics·Yuan LvZhongyi Cheng
Apr 3, 2021·International Journal of Molecular Sciences·Mirjana JerkicJohn G Laffey
Oct 5, 2019·Experimental Cell Research·Chen DongThorold W Theunissen
Apr 8, 2021·Stem Cells International·A S DevikaSmita Sudheer

Datasets Mentioned


Methods Mentioned

flow cytometry

Related Concepts

Cell Differentiation Process
Histone H7
RNA Polymerase II
Transcription, Genetic
v-myc Oncogenes
Histone Code
Epigenesis, Genetic
Mouse, Swiss

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