The transcriptional and mutational landscapes of lipid metabolism-related genes in colon cancer

Oncotarget
Lara P FernándezAna Ramírez de Molina

Abstract

Metabolic alterations encountered in tumors are well recognized and considered as a hallmark of cancer. In addition to Warburg Effect, epidemiological and experimental studies support the crucial role of lipid metabolism in colorectal cancer (CRC). The overexpression of four lipid metabolism-related genes (ABCA1, ACSL1, AGPAT1 and SCD genes) has been proposed as prognostic marker of stage II CRC (ColoLipidGene signature). In order to explore in depth the transcriptomic and genomic scenarios of ABCA1, ACSL1, AGPAT1 and SCD genes, we performed a transcriptomic meta-analysis in more than one thousand CRC individuals. Additionally we analyzed their genomic coding sequence in 95 patients, to find variants that could orchestrate CRC prognosis. We found that genetic variant rs3071, located on SCD gene, defines a 9.77% of stage II CRC patients with high risk of death. Moreover, individuals with upregulation of ABCA1 and AGPAT1 expression have an increased risk of CRC recurrence, independently of tumor stage. ABCA1 emerges as one of the main contributors to signature's prognostic effect. Indeed, both high ABCA1 expression and presence of tumoral genetic variants located in ABCA1 coding region, seem to be associated with CRC risk of deat...Continue Reading

References

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Citations

Feb 6, 2019·International Journal of Molecular Sciences·Anika Dutta, Neelam Sharma-Walia
Aug 14, 2019·Current Colorectal Cancer Reports·Rachel E BrownChristopher S Williams
Nov 17, 2020·Frontiers in Oncology·Lara P FernándezAna Ramírez de Molina
Sep 16, 2020·Seminars in Cancer Biology·Diego Gómez-CoronadoMaría E Fernández-Suárez
Apr 4, 2021·International Journal of Molecular Sciences·Aleksandra ZeljkovicBratislav Trifunovic

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Datasets Mentioned

BETA
GSE39582
GSE41258

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

ColoLipidGene
R
affymetrix R
Polyphen
SIFT
Variant Studio
Aroma
seTE

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