The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

Nature
J TorchiaM G Rosenfeld

Abstract

The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the cell as a complex with CBP and is required for transcriptional activity of nuclear receptors and other CBP/p300-dependent transcription factors. The highly related nuclear-receptor co-activator protein NCoA-1 is also specifically required for ligand-dependent activation of genes by nuclear receptors. p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that are required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways.

References

Dec 14, 1995·Nature·R L WagnerR J Fletterick
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·V CavaillèsM G Parker
Jan 1, 1994·Annual Review of Biochemistry·M J Tsai, B W O'Malley
Apr 1, 1994·Seminars in Cell Biology·P Chambon
Feb 1, 1994·Protein Engineering·C Geourjon, G Deléage
Mar 1, 1996·Genes & Development·P DaiS Ishii
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·H HongM R Stallcup
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·J D FondellR G Roeder
Sep 5, 1996·Nature·D ChakravartiR M Evans
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·C L SmithB W O'Malley
Sep 26, 1996·Nature·S BhattacharyaD M Livingston
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·T P YaoD M Livingston
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·B HansteinM Brown
Nov 8, 1996·The Journal of Biological Chemistry·D L SwopeJ C Chrivia
Dec 19, 1996·Nature·A J Bannister, T Kouzarides
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·J J ZhangJ E Darnell
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A E HorvaiC K Glass

❮ Previous
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Citations

Mar 26, 1998·Journal of Cellular Biochemistry·Y Berghöfer-HochheimerT Munder
Aug 31, 2001·Journal of Cellular Biochemistry·S ChakrabortyG Nucifora
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·B Sato
Jan 14, 2004·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Tatsuya Toyama, Hirotaka Iwase
Sep 1, 2004·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Carina M RivoltaHéctor M Targovnik
Sep 17, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Christian MorathJürgen Wagner
Feb 10, 2009·International Journal of Colorectal Disease·Petros D GrivasHaralabos Kalofonos
Nov 30, 2012·Chromosoma·Elisa FioritoAntoni Hurtado
May 7, 2009·Breast Cancer Research and Treatment·Tyler LahusenAnna T Riegel
Mar 11, 2011·Journal of Mammary Gland Biology and Neoplasia·Arja M Band, Marikki Laiho
Dec 18, 2004·Plant Molecular Biology·Ming-Jun GaoAbdelali Hannoufa
Sep 29, 1999·In Vitro Cellular & Developmental Biology. Animal·G NingJ Xu
Jul 16, 1999·Steroids·R Kumar, E B Thompson
Feb 16, 1999·Biochimica Et Biophysica Acta·H G StunnenbergJ L Betz
Aug 22, 2007·Trends in Cell Biology·J Lyon, N B La Thangue
Dec 15, 2010·Biochemistry·Yaroslava A Bulynko, Bert W O'Malley
Sep 6, 2008·Biochemistry·Obiamaka ObianyoPaul R Thompson
Oct 13, 2011·Chemical Reviews·Gregory S HarmonChristopher K Glass
Sep 19, 2006·Chemical Research in Toxicology·Tamara S DowersJudy L Bolton
Jan 5, 2002·Breast Cancer Research and Treatment·D O AzorsaP S Meltzer
Mar 20, 2013·Behavioral Neuroscience·Cynthia L BetheaKristine Coleman
Feb 16, 2011·Cell Research·Andrew J Bannister, Tony Kouzarides
Feb 10, 2009·Nature Cell Biology·Masashi KajiroJunn Yanagisawa
Aug 28, 2007·Nature Reviews. Cancer·Kelly A Green, Jason S Carroll
Aug 25, 2009·Nature Reviews. Cancer·Jianming XuBert W O'Malley
Mar 15, 2003·Nature Reviews. Cancer·Simak Ali, R Charles Coombes
Dec 23, 2009·Nature Reviews. Clinical Oncology·Ondrej GojisCarlo Palmieri
Feb 24, 2006·Nature Reviews. Immunology·Christopher K Glass, Sumito Ogawa
Feb 7, 2002·The Biochemical Journal·Valerie J PetersonMark Leid
May 26, 1999·The Plant Journal : for Cell and Molecular Biology·L D PyshP N Benfey
Sep 15, 2012·The Journal of Biological Chemistry·Zhaoting WuLingyi Chen
Apr 7, 2005·The Journal of Biological Chemistry·Zhanguo GaoJianping Ye

❮ Previous
Next ❯

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