The transcriptional landscape of seasonal coat colour moult in the snowshoe hare

Molecular Ecology
Mafalda S FerreiraJosé Melo-Ferreira

Abstract

Seasonal coat colour change is an important adaptation to seasonally changing environments but the evolution of this and other circannual traits remains poorly understood. In this study, we use gene expression to understand seasonal coat colour moulting in wild snowshoe hares (Lepus americanus). We used hair colour to follow the progression of the moult, simultaneously sampling skin from three moulting stages in hares collected during the peak of the spring moult from white winter to brown summer pelage. Using RNA sequencing, we tested whether patterns of expression were consistent with predictions based on the established phases of the hair growth cycle. We found functionally consistent clustering across skin types, with 766 genes differentially expressed between moult stages. "White" pelage showed more differentially expressed genes that were upregulated relative to other skin types, involved in the transition between late telogen (quiescent stage) and the onset of anagen (proliferative stage). Skin samples from transitional "intermediate" and "brown" pelage were transcriptionally similar and resembled the regressive transition to catagen (regressive stage). We also detected differential expression of several key circadian cl...Continue Reading

Associated Datasets

References

Nov 1, 1978·The Journal of Investigative Dermatology·A Logan, B Weatherhead
Jun 1, 1990·The British Journal of Dermatology·R PausR E Link
Mar 1, 1983·American Journal of Medical Genetics·K Lange, M Boehnke
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·H VrielingG S Barsh
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·D W InouyeB D Inouye
Jan 12, 2001·Physiological Reviews·K S Stenn, R Paus
May 16, 2001·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S RiederG Guérin
Nov 13, 2001·Developmental Cell·E FuchsR DasGupta
May 27, 2003·Journal of Cellular Physiology·Andrzej SlominskiJacobo Wortsman
Aug 5, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Vladimir A Botchkarev, Jiro Kishimoto
Apr 1, 1965·General and Comparative Endocrinology·C C RUST
Oct 30, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Ralf PausTaisuke Ito
May 27, 2004·Gene Expression Patterns : GEP·Thomas SchlakeThomas Boehm
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kevin K LinBogi Andersen
Feb 8, 2005·Genome Biology·Andrew Whitehead, Douglas L Crawford
Mar 29, 2005·The American Journal of Pathology·Eyal ZchariaMichael Elkin
Oct 3, 2006·Mechanisms of Development·Eli RavehUri Gat
Dec 23, 2006·Science·Gerald A LincolnDavid G Hazlerigg
Feb 17, 2007·Nature Reviews. Genetics·Gregory A Wray
May 12, 2007·Evolution; International Journal of Organic Evolution·Hopi E Hoekstra, Jerry A Coyne
Sep 28, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew J PaulMatthew P Butler
Dec 1, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alistair Dawson
Feb 17, 2009·Current Biology : CB·Giles E DuffieldJay C Dunlap
Mar 6, 2009·Genome Biology·Ben LangmeadSteven L Salzberg
Jul 25, 2009·PLoS Genetics·Kevin K LinBogi Andersen
Aug 29, 2009·Science·Catherine R LinnenHopi E Hoekstra
Oct 24, 2009·Nature Reviews. Molecular Cell Biology·Miguel Vicente-ManzanaresAlan Rick Horwitz
Nov 17, 2009·Molecular Ecology·Anne C DalzielPatricia M Schulte
Dec 17, 2009·BMC Bioinformatics·Christiam CamachoThomas L Madden
Jan 20, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Giuseppe Fusco, Alessandro Minelli

❮ Previous
Next ❯

Citations

Mar 6, 2018·Biological Reviews of the Cambridge Philosophical Society·Marketa ZimovaL Scott Mills
Apr 14, 2020·Evolution; International Journal of Organic Evolution·Matthew R JonesJeffrey M Good
Nov 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Iwona GiskaJosé Melo-Ferreira
Feb 23, 2020·Ecology and Evolution·Mafalda S FerreiraJosé Melo-Ferreira
Oct 27, 2020·Integrative and Comparative Biology·Sebastian G Alvarado
Dec 17, 2020·Proceedings. Biological Sciences·Marketa ZimovaL Scott Mills
Dec 3, 2020·Systematic Biology·Mafalda S FerreiraJosé Melo-Ferreira
Mar 5, 2021·Bio-protocol·Jukka-Pekka Verta, Felicity Jones
Aug 25, 2018·Current Opinion in Genetics & Development·Noah Snyder-Mackler, Amanda J Lea
Jun 23, 2021·Molecular Biology and Evolution·Inês MirandaJosé Melo-Ferreira
Aug 6, 2021·Scientific Reports·Jaakko L O PohjoismäkiSteve Smith
Mar 5, 2020··Jukka-Pekka VertaFelicity Jones

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.