The transcriptional regulator, Arg82, is a hybrid kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activity

FEBS Letters
T ZhangS B Shears

Abstract

The Arg82 gene of Saccharomyces cerevisiae encodes a transcriptional regulator that phosphorylates inositol 1,4,5-trisphosphate [Saiardi et al. (1999) Curr. Biol. 9, 1323-1326]. However, some controversy has surrounded the nature of the reaction products. We now show that Arg82 phosphorylates inositol 1,3,4,5-tetrakisphosphate to inositol pentakisphosphate, which is itself converted to two isomers of diphosphoinositol tetrakisphosphate, one of which has never previously been identified. One of the diphosphoinositol phosphates was further phosphorylated by a yeast cell lysate. We propose that Arg82 is an ancestral precursor of two distinct and specific enzyme families: inositol 1,4,5-trisphosphate kinases and diphosphoinositol polyphosphate synthases.

References

Jul 26, 1988·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R F IrvineK A Wreggett
Dec 5, 1998·Biochimica Et Biophysica Acta·S B Shears
Nov 24, 1999·FEBS Letters·M J SchellR F Irvine
Aug 17, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S B Shears
Aug 29, 2000·The Journal of Biological Chemistry·E B IvesJ D York
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·A SaiardiS H Snyder

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Citations

May 15, 2009·Molecular Pharmacology·Stephen B Shears
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Adolfo SaiardiSolomon H Snyder
Aug 29, 2009·Cellular and Molecular Life Sciences : CMLS·Christopher John BarkerPer-Olof Berggren
Jan 13, 2010·Cellular and Molecular Life Sciences : CMLS·Michael J Schell
Oct 25, 2013·The FEBS Journal·Mark P Thomas, Barry V L Potter
Mar 22, 2008·Chemistry & Biology·Petra DraskovicMarjetka Podobnik
Mar 23, 2002·Current Biology : CB·Melisa W Y HoStephen B Shears
Jan 20, 2017·Topics in Current Chemistry·Miranda S C Wilson, Adolfo Saiardi
Sep 13, 2002·The Journal of Biological Chemistry·Jill Stevenson-PaulikJohn D York
Oct 20, 2006·The Journal of Biological Chemistry·William Holmes, Gerwald Jogl
Mar 3, 2012·G3 : Genes - Genomes - Genetics·Gillian L FellAnne G Rosenwald
Feb 11, 2016·Biochemical Society Transactions·M Merced Malabanan, Raymond D Blind
Aug 7, 2018·MedChemComm·Andrew M RileyBarry V L Potter
Jan 11, 2021·Advances in Biological Regulation·Debabrata LahaAdolfo Saiardi
Jun 20, 2006·Biochimica Et Biophysica Acta·John D York

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