PMID: 11331422May 2, 2001Paper

The transcriptional regulator Yin Yang 1 activates the myelin PLP gene

Journal of Neurochemistry
J A BerndtL D Hudson

Abstract

Inauguration of the myelin program in developing oligodendrocytes requires the activation of those genes that encode the myelin proteins and the enzymes responsible for the synthesis and degradation of myelin lipids. An activator of the most abundantly expressed myelin protein, proteolipid protein (PLP), has been identified in a yeast one-hybrid system. The ubiquitously expressed zinc finger protein Yin Yang 1 (YY1) recognizes the myelin PLP promoter in vitro and in vivo. When overexpressed in an oligodendrocyte cell line, YY1 enhances transcription of the PLP promoter. A truncated version of YY1 that includes only the four zinc finger domains has little effect. The binding site for YY1 in the PLP promoter (site 3) fits the YY1 consensus site and DNA-protein complexes containing site 3 can be supershifted with an antibody directed against YY1 protein. Moreover, oligonucleotides with a mutated version of the PLP promoter site 3 are unable to bind to nuclear proteins or to compete for binding in a gel shift system. Finally, mutation of this site greatly reduces the activity of a 1-kb PLP promoter region in transfected glial cells. Our results suggest that PLP is a target gene for the transcriptional regulator YY1. This versatile ...Continue Reading

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Citations

Aug 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Chang J HuangJean de Vellis
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shu-Ting LinYing-Hui Fu
May 17, 2013·The Journal of Clinical Investigation·Mary Y HengYing-Hui Fu
Dec 15, 2010·PloS One·Carlos RiverosUNKNOWN ANZgene Multiple Sclerosis Genetics Consortium
Jan 18, 2012·Critical Reviews in Oncogenesis·Qiang ZhangGuangchao Sui
Feb 6, 2014·Translational Neurodegeneration·Shu-Ting LinYing-Hui Fu
Sep 2, 2008·Stem Cell Reviews·Raniero L PeruQ Richard Lu
Feb 14, 2004·Molecular and Cellular Neurosciences·Joseph A NielsenRegina C Armstrong
May 20, 2008·Journal of Neurochemistry·Ye He, Patrizia Casaccia-Bonnefil
Sep 11, 2009·Current Opinion in Neurobiology·Huiliang LiPatrizia Casaccia
Jun 19, 2009·Cell Adhesion & Migration·Sohail AhmedYuan Hong Yu
Sep 2, 2009·Genomics·Marcin Ratajewski, Lukasz Pulaski
Apr 1, 2014·American Journal of Human Genetics·Thomas PrukopMichael W Sereda
Jan 28, 2004·The Journal of Biological Chemistry·Chen-Yu WangWinston C Y Yu
Jun 28, 2008·Neurochemical Research·Marcin RylskiLeszek Kaczmarek

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