The transcriptional repressor Blimp-1 acts downstream of BMP signaling to generate primordial germ cells in the cricket Gryllus bimaculatus

Development
Taro Nakamura, Cassandra G Extavour

Abstract

Segregation of the germ line from the soma is an essential event for transmission of genetic information across generations in all sexually reproducing animals. Although some well-studied systems such as Drosophila and Xenopus use maternally inherited germ determinants to specify germ cells, most animals, including mice, appear to utilize zygotic inductive cell signals to specify germ cells during later embryogenesis. Such inductive germ cell specification is thought to be an ancestral trait of Bilateria, but major questions remain as to the nature of an ancestral mechanism to induce germ cells, and how that mechanism evolved. We previously reported that BMP signaling-based germ cell induction is conserved in both the mouse Mus musculus and the cricket Gryllus bimaculatus, which is an emerging model organism for functional studies of induction-based germ cell formation. In order to gain further insight into the functional evolution of germ cell specification, here we examined the Gryllus ortholog of the transcription factor Blimp-1 (also known as Prdm1), which is a widely conserved bilaterian gene known to play a crucial role in the specification of germ cells in mice. Our functional analyses of the Gryllus Blimp-1 ortholog rev...Continue Reading

References

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Citations

Apr 19, 2016·Current Opinion in Insect Science·Honghu Quan, Jeremy A Lynch
Nov 17, 2017·Journal of Cellular Biochemistry·Wenhui ZhangBichun Li
Jul 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Austen A BarnettCassandra G Extavour
Feb 15, 2020·Science·Timothy Q DuBucUri Frank
Jun 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Carrie A Whittle, Cassandra G Extavour
Feb 13, 2019·BMC Evolutionary Biology·Carrie A Whittle, Cassandra G Extavour
Jul 24, 2021·Development Genes and Evolution·Hajime Nakao

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