PMID: 9442378Jan 27, 1998Paper

The transcriptional silencer protein NRF: a repressor of NF-kappa B enhancers

Immunobiology
Mahtab Nourbakhsh, H Hauser

Abstract

NF-kappa B/rel proteins are present in most cell types. In concert with other transcriptional factors they regulate a variety of genes which contribute to a wide spectrum of physiological activities like inflammation and apoptosis. An excellent example of this combinatorial regulation takes place in the IFN-beta promoter. In this promoter the fundamental regulatory elements are assembled within less than 100 base pairs including a NF-kappa B/rel enhancer and a negative regulatory element, called NRE. NRE is a member of a new class of transcriptional repressor sequences with a silencing capacity targeted to the NF-kappa B/rel enhancer. NRF is a novel transcriptional factor that binds to NRE. NRF belongs to a major class of transcriptional repressors that interact with specific promoter elements and repress transcription by separable repression domains. Such molecules have been termed active repressors, because they act by inhibitory protein-protein interaction and not simply by steric hindrance.

References

Feb 1, 1992·AIDS Research and Human Retroviruses·M RoedererL A Herzenberg
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore

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Citations

Dec 29, 1998·Biochimie·S Lopez, S Navarro
Mar 25, 2000·Molecular and Cellular Biology·A OumardM Nourbakhsh
Dec 16, 2005·Molecular and Cellular Biology·Natali FroeseHansjörg Hauser
May 12, 2012·Journal of Theoretical Biology·Aylin Günel
Feb 6, 2020·The Biochemical Journal·Jana AlexandrovaAnne E Willis
Jan 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Xin-Jie ChenSai-Juan Chen
Apr 16, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Alessia AzzaràFiorella Gurrieri
Jul 1, 2004·Journal of Cell Science·Ina NiedickMario Köster

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