The Transcriptome of Type I Murine Astrocytes under Interferon-Gamma Exposure and Remyelination Stimulus

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Anna KudriaevaA A Belogurov

Abstract

Astrocytes are considered to be an important contributor to central nervous system (CNS) disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected by cytokines released by lymphocytes, penetrating the blood-brain barrier-in particular, the classical pro-inflammatory cytokine interferon-gamma (IFNγ). We report here the transcriptomal profiling of astrocytes treated using IFNγ and benztropine, a putative remyelinization agent. Our findings indicate that the expression of genes involved in antigen processing and presentation in astrocytes are significantly upregulated upon IFNγ exposure, emphasizing the critical role of this cytokine in the redirection of immune response towards self-antigens. Data reported herein support previous observations that the IFNγ-induced JAK-STAT signaling pathway may be regarded as a valuable target for pharmaceutical interventions.

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Citations

Jan 11, 2019·Bulletin of Experimental Biology and Medicine·D V Mal'tsevaS A Rodin
Mar 23, 2018·Brain Sciences·Anne-Cécile BoulayMartine Cohen-Salmon
Oct 30, 2020·Doklady. Biochemistry and Biophysics·D V MaltsevaE N Knyazev

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Datasets Mentioned

BETA
GSE96899

Methods Mentioned

BETA
GTPases
PCR

Software Mentioned

Affymetrix Expression Console

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