The transcriptomic signature of different sexes in two protogynous hermaphrodites: Insights into the molecular network underlying sex phenotype in fish

Scientific Reports
A TsakogiannisCostas Tsigenopoulos

Abstract

Sex differentiation is a puzzling problem in fish due to the variety of reproductive systems and the flexibility of their sex determination mechanisms. The Sparidae, a teleost family, reflects this remarkable diversity of sexual mechanisms found in fish. Our aim was to capture the transcriptomic signature of different sexes in two protogynous hermaphrodite sparids, the common pandora Pagellus erythrinus and the red porgy Pagrus pagrus in order to shed light on the molecular network contributing to either the female or the male phenotype in these organisms. Through RNA sequencing, we investigated sex-specific differences in gene expression in both species' brains and gonads. The analysis revealed common male and female specific genes/pathways between these protogynous fish. Whereas limited sex differences found in the brain indicate a sexually plastic tissue, in contrast, the great amount of sex-biased genes observed in gonads reflects the functional divergence of the transformed tissue to either its male or female character. Α common "crew" of well-known molecular players is acting to preserve either sex identity of the gonad in these fish. Lastly, this study lays the ground for a deeper understanding of the complex process of ...Continue Reading

References

Nov 24, 1975·Science·R R WarnerE G Leigh
Feb 1, 1992·The Journal of Experimental Zoology·D Y Shapiro
May 9, 1991·Nature·P KoopmanR Lovell-Badge
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jun 1, 1985·Journal of Clinical Pathology·N A AthanasouD J Weatherall
Jun 1, 1997·Current Opinion in Genetics & Development·L H Pevny, R Lovell-Badge
Mar 7, 1998·Nature·C S RaymondD Zarkower
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·R OverbeekN Maltsev
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
May 29, 2000·Trends in Genetics : TIG·P RiceA Bleasby
Sep 5, 2002·Molecular Reproduction and Development·Hayato YokoiKenjiro Ozato
Jan 15, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Daisuke UchidaTaisen Iguchi
Jun 23, 2004·Biochemical and Biophysical Research Communications·Deshou WangYoshitaka Nagahama
Aug 28, 2004·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·John E Richards
Nov 25, 2004·The Journal of Comparative Neurology·Sabrina S Burmeister, Russell D Fernald
Apr 16, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Rama S Singh, Rob J Kulathinal
May 14, 2005·Annals of the New York Academy of Sciences·Guan-Chung WuChing-Fong Chang
Jun 28, 2005·Nucleic Acids Research·E QuevillonR Lopez
Nov 12, 2005·Reproductive Biology and Endocrinology : RB&E·Jonas von Hofsten, Per-Erik Olsson
Mar 18, 2006·Arquivos brasileiros de endocrinologia e metabologia·Ursula Mittwoch
Apr 25, 2006·Biochemical and Biophysical Research Communications·Masatoshi NakamotoNaoki Shibata
Jun 22, 2006·Bioinformatics·Simen MyhreAstrid Laegreid
Jul 18, 2006·Nucleic Acids Research·Jia YeJun Wang
Feb 20, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·C A Wilson, D C Davies
Apr 17, 2007·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Bo YaoJian-Fang Gui
Aug 30, 2007·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Makiko KarubeReynaldo Patiño
Dec 21, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tohru KobayashiYoshitaka Nagahama
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shin YoshimotoMichihiko Ito
Apr 9, 2008·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·J-N VolffM Schartl

❮ Previous
Next ❯

Citations

Feb 7, 2020·Biological Reviews of the Cambridge Philosophical Society·Meghan A CastelliClare E Holleley
Feb 5, 2019·Frontiers in Genetics·Alexandros TsakogiannisCostas S Tsigenopoulos
Apr 7, 2020·Scientific Reports·Surintorn BoonanuntanasarnUthairat Na-Nakorn
Oct 9, 2021·Genome Biology and Evolution·Corentin DechaudMagali Naville

❮ Previous
Next ❯

Datasets Mentioned

BETA
PRJNA395994

Methods Mentioned

BETA
PCA

Software Mentioned

Trimmomatic
BLAST
BLASTx
Prinseq
Scythe
R
NOBLAST
Trinity package
Bowtie2
Blast2GO

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.