The transfer functions of cardiac tissue during stochastic pacing.

Biophysical Journal
Enno de Lange, Jan P Kucera

Abstract

The restitution properties of cardiac action potential duration (APD) and conduction velocity (CV) are important factors in arrhythmogenesis. They determine alternans, wavebreak, and the patterns of reentrant arrhythmias. We developed a novel approach to characterize restitution using transfer functions. Transfer functions relate an input and an output quantity in terms of gain and phase shift in the complex frequency domain. We derived an analytical expression for the transfer function of interbeat intervals (IBIs) during conduction from one site (input) to another site downstream (output). Transfer functions can be efficiently obtained using a stochastic pacing protocol. Using simulations of conduction and extracellular mapping of strands of neonatal rat ventricular myocytes, we show that transfer functions permit the quantification of APD and CV restitution slopes when it is difficult to measure APD directly. We find that the normally positive CV restitution slope attenuates IBI variations. In contrast, a negative CV restitution slope (induced by decreasing extracellular [K(+)]) amplifies IBI variations with a maximum at the frequency of alternans. Hence, it potentiates alternans and renders conduction unstable, even in the ...Continue Reading

References

Jan 1, 1991·Journal of Mathematical Biology·J P Keener
Nov 1, 1974·Circulation Research·J F Spear, E N Moore
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·A GarfinkelP S Chen
Aug 19, 2000·Haemophilia : the Official Journal of the World Federation of Hemophilia·R Ljung
May 30, 2001·Cardiovascular Research·C Antzelevitch
Apr 12, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·E G TolkachevaW Krassowska
Apr 20, 2004·Journal of Cardiovascular Electrophysiology·Isabelle BanvilleRichard A Gray
Jun 4, 2004·Journal of Cardiovascular Electrophysiology·Soma S KalbDaniel J Gauthier
Oct 16, 2004·Journal of Cardiovascular Electrophysiology·Bum-Rak ChoiGuy Salama
Jul 23, 2005·Chaos·Soma S KalbWanda Krassowska
Jan 24, 2006·Journal of Cardiovascular Electrophysiology·Runze Wu, Abhijit Patwardhan
Feb 18, 2006·Circulation Research·Michele MiragoliStephan Rohr
May 27, 2006·Circulation Research·James N WeissZhilin Qu
Jun 19, 2007·Experimental Physiology·Massimiliano ZaniboniNicolò Salvarani

❮ Previous
Next ❯

Citations

Mar 8, 2012·PLoS Computational Biology·Mathieu LemayJan P Kucera
Oct 1, 2014·Physics Reports·Zhilin QuJames N Weiss
Jan 19, 2016·Frontiers in Physiology·Linyuan JingAbhijit Patwardhan
Jan 15, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Okyu KwonKyoung J Lee
Oct 29, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Marek MalikE Marcel van Gelderen
May 24, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Blas EchebarriaMarkus Bär

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.