The transferability of a candidate reference method for determination of creatinine in serum

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
L ZwangJ van Pelt

Abstract

We developed a candidate reference method for the determination of creatinine in serum. For the acceptance of a reference method it is important that it be rigorously validated against a definitive method and that the method can be transferred from one laboratory to another. This study focussed on the transferability and consisted of two parts: introduction and familiarization with the method in four clinical chemistry laboratories in the Netherlands, followed by independent measurements of Standard Reference Material 909a2 and several commercial quality control materials provided with reference method values according to the protocol of the German Quality Assessment Organisation. The criterion for judging transferability was the mean total error (%) of the five sera used in the accuracy experiment. For creatinine we used a total error of < 2.2%. For Standard Reference Material 909a2 all four laboratories were able to comply with this demand, while only two laboratories met this requirement for the other four sera. The results for the Standard Reference Material 909a2 from the collaborating laboratories demonstrate that this candidate reference method can be successfully transferred without loss of precision and accuracy.

References


❮ Previous
Next ❯

Citations

Sep 19, 1998·Clinical Biochemistry·C Franzini, F Ceriotti
Mar 19, 2008·Reproductive Biology and Endocrinology : RB&E·Nikorn ThongtipAnuchai Pinyopummin
Jun 27, 2014·PloS One·Chang-Rong TianJiang-Tao Wen
Jan 20, 2012·Toxicology and Industrial Health·Dilshad Ahmed KhanMuhammad Qaiser Alam Khan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
M WillsM H Kroll
European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
G CattozzoC Franzini
European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
L ArcangeliL Scapellato
© 2021 Meta ULC. All rights reserved