Oct 16, 1989

The transformation-sensitive heat shock protein (hsp47) binds specifically to Fetuin

Biochemical and Biophysical Research Communications
A NakaiK Nagata

Abstract

The transformation-sensitive heat shock protein of Mr = 47,000 (hsp47) has been shown to bind to collagen and gelatin. We examined the binding specificity of hsp47. The binding of hsp47 to gelatin-Sepharose 4B was competitively inhibited by fetuin as effectively as by gelatin or collagen, whereas a variety of other proteins tested had no effect. Fetuin-coupled Sepharose 4B was found to bind hsp47 even at high ionic strength, but the complex was dissociated at pH less than or equal to 5.5.)

Mentioned in this Paper

Heat shock proteins
SDS-PAGE
SERPINH1
SERPINH1 gene
Binding (Molecular Function)
Chick Embryo
Fibroblasts
Sepharose 4B
Collagen Location
2D Polyacrylamide Gel Electrophoresis

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