The transient cortical zone in the adrenal gland: the mystery of the adrenal X-zone

The Journal of Endocrinology
Yuan Kang

Abstract

The X-zone is a transient cortical region enriched in eosinophilic cells located in the cortical-medullary boundary of the mouse adrenal gland. Similar to the X-zone, the fetal zone in human adrenals is also a transient cortical compartment, comprising the majority of the human fetal adrenal gland. During adrenal development, fetal cortical cells are gradually replaced by newly formed adult cortical cells that develop into outer definitive zones. In mice, the regression of this fetal cell population is sexually dimorphic. Many mouse models with mutations associated with endocrine factors have been reported with X-zone phenotypes. Increasing findings indicate that the cell fate of this aged cell population of the adrenal cortex can be manipulated by many hormonal and nonhormonal factors. This review summarizes the current knowledge of this transient adrenocortical zone with an emphasis on genes and signaling pathways that affect X-zone cells.

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Citations

Mar 8, 2021·Molecular and Cellular Endocrinology·Typhanie Dumontet, Antoine Martinez
Jun 7, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xingwang LiRen-Shan Ge
Apr 3, 2021·Molecular and Cellular Endocrinology·Nicole BechmannCharlotte Steenblock
May 1, 2021·International Journal of Molecular Sciences·Angela L CumberlandDavid W Walker
May 21, 2021·Nature Reviews. Endocrinology·Rodanthi Lyraki, Andreas Schedl
Jun 3, 2021·International Journal of Molecular Sciences·Rodanthi Lyraki, Andreas Schedl
Aug 20, 2019·Chemical Research in Toxicology·Xiuxiu ChenRen-Shan Ge
Sep 21, 2021·Laboratory Animals·Athanasios SiasiosIoannis Grivas
Jan 20, 2022·Thyroid : Official Journal of the American Thyroid Association·Konrad PatyraJukka Kero

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