The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis

Mediators of Inflammation
Joel Jesús Toledo-MauriñoJesús K Yamamoto-Furusho

Abstract

The transient receptor potential vanilloid 1 (TRPV1) may play a role in the pathogenesis of ulcerative colitis (UC). The aim of the study was to determine the gene and protein expression of TRPV1 in UC patients and noninflamed controls. Gene expression was performed by RT-PCR, and protein expression was performed by immunohistochemistry. The gene expression of TRPV1 was significantly increased in the remission UC group compared to active UC patients (P = 0.002), and an upregulation of the TRPV1 gene was associated with clinical outcomes such as age at diagnosis (<40 years) (P = 0.02) and clinical disease course characterized by relapsing and continuous activity (P = 0.07). TRPV1 immunoreactive cells were conspicuously higher in all intestinal layers from active UC patients compared with noninflamed control tissue. These findings suggest that TRPV1 might be involved in UC pathogenesis.

References

Dec 24, 1987·The New England Journal of Medicine·K W SchroederD M Ilstrup
Aug 24, 2004·Current Medicinal Chemistry. Cardiovascular and Hematological Agents·Prashant Vaishnava, Donna H Wang
Sep 28, 2004·American Journal of Respiratory and Critical Care Medicine·David A GronebergK Fan Chung
Dec 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E S KimballP J Hornby
Jan 4, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·F MassaB Lutz
Jun 29, 2006·Inflammatory Bowel Diseases·Magne HenriksenUNKNOWN IBSEN Study Group
Jan 16, 2007·Handbook of Experimental Pharmacology·E C SchwarzM Hoth
Mar 3, 2007·The Journal of Clinical Investigation·Warren StroberPeter Mannon
Jun 21, 2007·Annual Review of Biochemistry·Kartik Venkatachalam, Craig Montell
Jul 3, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Natalie ClarkSusan D Brain
Jul 27, 2007·Nature·R J Xavier, D K Podolsky
Jul 11, 2008·Current Neuropharmacology·Angel MesseguerAntonio Ferrer-Montiel
Nov 10, 2009·Pharmacology & Therapeutics·Khadija Alawi, Julie Keeble
Mar 3, 2010·Annual Review of Immunology·Arthur KaserRichard S Blumberg
Apr 23, 2010·Journal of Molecular Neuroscience : MN·Istvan SzitterErika Pinter
Mar 7, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D de FontgallandD A Wattchow
Jun 9, 2015·Frontiers in Immunology·Lilian L NoharaWilfred A Jefferies

❮ Previous
Next ❯

Citations

Mar 11, 2020·Frontiers in Immunology·Yiding ChenHu Zhang
May 27, 2020·Journal of Immunology Research·Joel J Toledo MauriñoJesus K Yamamoto-Furusho
Sep 19, 2020·European Journal of Pharmacology·Vijay KumarMahendra Bishnoi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
antisense oligonucleotides

Software Mentioned

Pro Plus
SigmaStat
SPSS
Image

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.