The transient ventilatory response to carbon dioxide at rest and in exercise in man

Respiration Physiology
M S JacobiK B Saunders

Abstract

A new technique has been developed to measure the transient response to inhaled CO2 using 30 sec pulses at constant inflow. Multiple experiments are ensemble-averaged in order to define the resulting small signals. We measured the peak changes in ventilation (delta V') and in PCO2 (delta PCO2), taking the ratio (delta V'/delta PCO2) as an index of response. Six healthy volunteers performed experiments at rest, 50 W and 100 W exercise. Three runs, each containing three pulses, were performed at each workload and subsequently averaged. Analysis of variance showed no significant difference between successive pulses or among subjects. delta V' did not differ significantly with workload, but delta PCO2 was progressively smaller as workload increased, and hence the response, delta V'/delta PCO2, greater. The delay between the rise in PCO2 and the rise in ventilation was also progressively shorter as workload increased, being 16-18 sec at rest, 7-13 sec at 50 W, and 3-6 sec at 100 W. Our results suggest that there is increased sensitivity to CO2 in exercise, which may be due to progressive activation of the peripheral chemoreceptors as work load increases. The delay at rest is too long for the peripheral chemoreceptor. Therefore, with...Continue Reading

References

May 1, 1979·Archives internationales de physiologie et de biochimie·Y JammesC Grimaud
Apr 1, 1973·Respiration Physiology·N H EdelmanN S Cherniack
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Citations

Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·A K McConnellC T Davies
May 1, 1991·Respiration Physiology·A R CumminK B Saunders
Feb 1, 1995·Respiration Physiology·S S Fernando, K B Saunders
Jul 1, 1996·Respiration Physiology·K NiizekiY Miyamoto
Dec 7, 1992·Journal of Theoretical Biology·K B Saunders, A R Cummin
Jan 26, 2008·Journal of Applied Physiology·David A LowCraig G Crandall
Oct 29, 2003·American Journal of Respiratory and Critical Care Medicine·Yoshiyuki FukuokaHaruo Ikegami
Jul 19, 2005·Journal of Applied Physiology·Stuart ThomsonStephen J Semple

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