The transition from viral to autoimmune myocarditis

Autoimmunity
S L Hill, N R Rose

Abstract

Myocarditis offers a unique opportunity to study the factors contributing to its transition from a viral infection to an autoimmune disease. In this article, we review recent studies on the role of nitric oxide (NO), gamma interferon (IFN-gamma) and interleukin 12 (IL-12) in the progression from early (viral) to late (autoimmune) phases of myocarditis induced by Coxsackievirus B3 (CB3) in highly susceptible (A.CA) and moderately susceptible (B10.M) mice. NO plays a paradoxical role, being protective in early stages but detrimental later in the course of disease. Treatment with antibody to IFN-gamma reduced early disease, but had little effect on the severity of cardiac lesions at later times. Treatment with recombinant (r) IL-12 significantly reduced the autoimmune cardiac lesions in moderately susceptible B10.M mice, but had no measurable effect in highly susceptible A.CA animals. These studies provide evidence that the profile of inflammatory mediators produced early in the course of viral infection determines the later development of autoimmune disease.

References

Jun 1, 1985·Journal of Molecular and Cellular Cardiology·H P Schultheiss, H D Bolte
Oct 1, 1974·The Journal of Hygiene·N R Grist, E J Bell
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Aug 24, 1995·Biochemical and Biophysical Research Communications·C V Oddis, M S Finkel
Feb 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·M FieldsW E Antholine
Mar 27, 1996·Biochemical and Biophysical Research Communications·S MikamiM Yokoyama
Apr 15, 1996·The Journal of Clinical Investigation·C J LowensteinA Herskowitz
Aug 17, 2000·Immunologic Research·V K SinghS S Agarwal
Nov 9, 2000·The New England Journal of Medicine·A M Feldman, D McNamara

❮ Previous
Next ❯

Citations

Sep 24, 2004·Reviews in Medical Virology·DeLisa FairweatherNoel R Rose
Nov 7, 2002·International Journal of Cardiology·James D FettGerald F Combs
May 25, 2005·Journal of Child and Adolescent Psychopharmacology·Pieter J HoekstraRuud B Minderaa
Sep 29, 2004·Journal of Virology·Roberta L DeBiasiKenneth L Tyler
Mar 6, 2003·The Journal of Clinical Investigation·Nir GrabieAndrew H Lichtman
Jun 10, 2010·Expert Review of Cardiovascular Therapy·James D Fett
Sep 29, 2011·International Journal of Cardiology·James D Fett, Charles F McTiernan
Jul 6, 2010·Experimental and Molecular Pathology·Jobert G BarinDaniela Ciháková
Jun 9, 2007·The American Journal of Pathology·Kurt ReifenbergJürgen Löhler
Jun 18, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J D FettJ G Murphy
Mar 10, 2011·Expert Opinion on Therapeutic Targets·Ulrich HofmannStefan Frantz
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ya LiMadeleine W Cunningham
Aug 7, 2003·Trends in Genetics : TIG·Seung-Hwan LeeSilvia M Vidal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.