The transition to cocaine addiction: the importance of pharmacokinetics for preclinical models

Psychopharmacology
Alex B KawaAnne-Noël Samaha

Abstract

A key question in addiction research concerns how, in some individuals, initial recreational or casual patterns of drug use may change brain and psychological function in ways that promote a transition to the problematic patterns of use that define substance use disorders (addiction). In preclinical studies, this is modeled using self-administration procedures. However, most cocaine self-administration procedures produce continuously high brain concentrations of drug, whereas in people, bouts of use are thought to be more intermittent. Here, we ask whether such temporal pharmacokinetic factors matter, by comparing and contrasting the neuropsychological consequences of intermittent vs. long access cocaine self-administration experience. It turns out, the temporal pattern of cocaine use has profound effects on a number of outcomes. First, despite much less total drug consumption, intermittent access to cocaine is more effective in producing addiction-like behavior. Second, intermittent and long access cocaine self-administration change the brain in very different ways to influence motivated behavior. We argue that intermittent access self-administration procedures might be better suited than traditional self-administration proced...Continue Reading

References

Jan 1, 1976·Pharmacology, Biochemistry, and Behavior·C E JohansonK Bonese
Jan 1, 1976·Annals of the New York Academy of Sciences·E H EllinwoodM M Kilbey
Feb 1, 1989·Archives of General Psychiatry·M L GriffinU Lange
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·C A Dackis, M S Gold
Jan 1, 1969·Annual Review of Pharmacology·C R Schuster, T Thompson
Mar 16, 1984·European Journal of Pharmacology·S D Glick, P A Hinds
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Jan 1, 1993·Journal of Substance Abuse Treatment·T A KostenB J Rounsaville
Aug 1, 1997·Psychopharmacology·A S WardR W Foltin
Aug 24, 1999·The European Journal of Neuroscience·V DerocheP V Piazza
Dec 22, 1999·The American Journal on Addictions·E F McCance-KatzB J Rounsaville
Mar 4, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S H AhmedG F Koob
Feb 8, 2002·Journal of Addictive Diseases·Sara L SimonWalter Ling
Dec 21, 2002·Addiction·Francesco LeriJane Stewart
Nov 20, 2003·Neuroreport·Neil E Paterson, Athina Markou
May 26, 2004·Physiology & Behavior·Kent C Berridge
Aug 18, 2004·Science·Véronique Deroche-GamonetPier Vincenzo Piazza
Nov 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leigh V PanlilioSteven R Goldberg
Aug 16, 2005·Biological Psychiatry·Carrie R FerrarioTerry E Robinson
Nov 1, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Magalie Lenoir, Serge H Ahmed
Feb 20, 2008·Psychopharmacology·Margaret Haney, Roger Spealman
Feb 29, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa A BriandTerry E Robinson
Jul 22, 2008·Biological Psychiatry·David BelinVéronique Deroche-Gamonet
Aug 2, 2008·Alcoholism, Clinical and Experimental Research·Jeffrey A SimmsSelena E Bartlett
Oct 31, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erik B Oleson, David C S Roberts
Aug 19, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin A ZimmerDavid C S Roberts
Aug 26, 2011·Neuroscience·S H Ahmed
Mar 29, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin A ZimmerDavid Cs Roberts

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Citations

Apr 11, 2019·The European Journal of Neuroscience·Alex B KawaTerry E Robinson
Jun 20, 2019·Frontiers in Psychiatry·Davide AmatoAndreas Heinz
Feb 23, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emilia M LefevrePatrick E Rothwell
Apr 2, 2020·Médecine sciences : M/S·Florence Allain, Anne-Noël Samaha
Feb 15, 2020·Alcoholism, Clinical and Experimental Research·Linda Patia Spear
Jul 19, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Florence AllainAnne-Noël Samaha
Mar 3, 2020·Frontiers in Behavioral Neuroscience·M Carmen ArenasCarmen Manzanedo
Oct 8, 2020·Nature Reviews. Neuroscience·Marco VenniroYavin Shaham
Nov 11, 2020·Scientific Reports·Nazzareno CannellaRainer Spanagel
Nov 25, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ani GasparyanJorge Manzanares
Apr 25, 2021·Trends in Neurosciences·Anne-Noël SamahaTerry E Robinson
Jul 29, 2021·Trends in Neurosciences·Terry E RobinsonAnne-Noël Samaha
Jun 10, 2020·Cold Spring Harbor Perspectives in Medicine·Louk J M J Vanderschuren, Serge H Ahmed

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