PMID: 8612606Mar 1, 1996Paper

The translational cis-regulatory element of mammalian ribosomal protein mRNAs is recognized by the plant translational apparatus

European Journal of Biochemistry
S Shama, O Meyuhas

Abstract

The translational efficiency of mammalian ribosomal protein mRNAs correlates with the growth status of the cells and its control is mediated through a 5' terminal oligopyrimidine tract (5' TOP) common to all these mRNAs. In the present study, we demonstrate that the plant translational apparatus, as represented by wheat-germ extract, discriminates against mammalian mRNAs containing this motif to the same extent as do quiescent mammalian cells. Moreover, mutations in the 5' TOP, which abolish the growth-dependent translational control of the respective mRNAs in mammalian cells, render these mRNAs refractory to discrimination in the plant cell-free system. This selective discrimination reflects neither the specific instability of 5' TOP-containing mRNAs during the incubation in vitro nor a lower competitive potential for the cap-binding protein. The lower in vitro translational efficiency of these mRNAs is an inherent feature which is independent of whether they were derived from polysomes or messenger ribonucleoprotein particles of the transfected mammalian cells. The conservation of the discriminatory property of the translational apparatus between the animal and plant kingdoms is discussed from mechanistic and evolutionary poi...Continue Reading

References

Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S LevyO Meyuhas
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W E WaldenR E Thach
Oct 1, 1985·Developmental Biology·E Z Baum, W M Wormington
Jan 15, 1993·Biochemical and Biophysical Research Communications·U HojaT Dingermann
Nov 16, 1993·Biochimica Et Biophysica Acta·V SangwanJ S Gantt
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·N TeradaE W Gelfand
Jul 1, 1994·Plant Physiology·T R LenvikJ S Gantt
Jun 1, 1994·Genetics·S AnderssonM Jacobs-Lorena

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Citations

Oct 24, 2000·The Biochemical Journal·T D DinkovaE Sánchez de Jiménez
Oct 13, 2000·European Journal of Biochemistry·O Meyuhas
Oct 13, 2001·Plant Physiology·A BarakatJ Bailey-Serres
Sep 3, 2011·Genome Génome / Conseil National De Recherches Canada·Kerri B McIntoshPeta C Bonham-Smith
May 15, 2008·BMC Evolutionary Biology·Olga AndrésMontserrat Bosch
Jan 19, 2012·Molecular Systems Biology·Ming-Jung LiuShu-Hsing Wu
Sep 23, 2014·Biochimica Et Biophysica Acta·Oded Meyuhas, Tamar Kahan
Dec 9, 2014·Biochimica Et Biophysica Acta·Paul AndersonPavel Ivanov
Jan 19, 2002·Nature Genetics·Michele MorganteWayne Powell
Jan 18, 2018·Wiley Interdisciplinary Reviews. RNA·Robert F HarveyAnne E Willis
Sep 6, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T TakahashiK Yonezawa
Jan 19, 1999·Annual Review of Cell and Developmental Biology·N K Gray, M Wickens
Feb 17, 2017·Biochemical Society Transactions·Carson C Thoreen

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