The translational regulator eIF3a: the tricky eIF3 subunit!

Biochimica Et Biophysica Acta
Federica SalettaDes R Richardson

Abstract

Regulation of gene expression is a fundamental step in cellular physiology as abnormalities in this process may lead to de-regulated growth and cancer. Translation of mRNA is mainly regulated at the rate-limiting initiation step, where many eukaryotic initiation factors (eIFs) are involved. The largest and most complex initiation factor is eIF3 which plays a role in translational regulation, cell growth and cancer. The largest subunit of eIF3 is eIF3a, although it is not required for the general function of eIF3 in translation initiation. However, eIF3a may play a role as a regulator of a subset of mRNAs and has been demonstrated to regulate the expression of p27(kip1), tyrosinated α-tubulin and ribonucleotide reductase M2 subunit. These molecules have a pivotal role in the regulation of the cell cycle. Moreover, the eIF3a mRNA is ubiquitously expressed in all tissues at different levels and is found elevated in a number of cancer types. eIF3a can modulate the cell cycle and may be a translational regulator for proteins important for entrance into S phase. The expression of eIF3a is decreased in differentiated cells in culture and the suppression of eIF3a expression can reverse the malignant phenotype and change the sensitivity...Continue Reading

References

Dec 17, 1979·Biochimica Et Biophysica Acta·H Trachsel, T Staehelin
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R Benne, J W Hershey
Mar 11, 1975·Biochemistry·K E Smith, E C Henshaw
Jan 1, 1992·Annual Review of Cell Biology·M Kozak
Dec 1, 1990·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J A WrightA Y Tagger
Feb 1, 1990·Experimental Cell Research·M Lalande
Nov 3, 1989·Science·A B Pardee
Nov 28, 1971·Journal of Molecular Biology·G D Pearson, P C Hanawalt
Jan 1, 1982·Annual Review of Biochemistry·U MaitraA Chaudhuri
Dec 15, 1995·European Journal of Biochemistry·N van BelzenF T Bosman
Aug 31, 1995·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·T NagaseN Nomura
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·H FanJ A Wright
Dec 1, 1996·The Journal of Cell Biology·M L Gonzalez-Garay, F Cabral
Jan 7, 1998·Molecular and Cellular Biology·A GradiN Sonenberg
Feb 7, 1998·Science·A Hall
Jun 30, 1998·Trends in Biochemical Sciences·K Hofmann, P Bucher

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Citations

Feb 9, 2013·Carcinogenesis·Ji-Ye YinJian-Ting Zhang
Apr 8, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Wen-Qun LiYuan-Jian Li
Mar 18, 2016·Cell Cycle·Marina ToompuuCecilia Sarmiento
Jan 17, 2015·European Journal of Pharmacology·Xian-Wei LiYuan-Jian Li
Apr 7, 2018·Wiley Interdisciplinary Reviews. RNA·Nikolay E Shirokikh, Thomas Preiss
Jun 15, 2019·Cancer Medicine·Ma-Sha HuangZhao-Qian Liu
Oct 28, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Martin A LauxmannVeronica I Dodero

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