The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state

Biochimica Et Biophysica Acta
Dmitrij A LisakAxel Methner

Abstract

Bax inhibitor-1 (BI-1) is an evolutionarily conserved pH-dependent Ca²⁺ leak channel in the endoplasmic reticulum and the founding member of a family of six highly hydrophobic mammalian proteins named transmembrane BAX inhibitor motif containing (TMBIM) 1-6 with BI-1 being TMBIM6. Here we compared the structure, subcellular localization, tissue expression and the effect on the cellular Ca²⁺ homeostasis of all family members side by side. We found that all TMBIM proteins possess the di-aspartyl pH sensor responsible for pH sensing identified in TMBIM6 and its bacterial homologue BsYetJ. TMBIM1-3 and TMBIM4-6 represent two phylogenetically distinct groups that are localized in the Golgi apparatus (TMBIM1-3), endoplasmic reticulum (TMBIM4-6) or mitochondria (TMBIM5) but share a common structure of at least seven transmembrane domains with the last domain being semi-hydrophobic. TMBIM1 is mainly expressed in muscle, TMBIM2 and 3 in the nervous system, TMBIM4 and 5 are ubiquitously expressed and TMBIM6 in skeletal muscle, kidney, liver and spleen. All TMBIM proteins reduce the Ca²⁺ content of the endoplasmic reticulum, and all but TMBIM5 also reduce the cytosolic resting Ca²⁺ concentration. These results suggest that the TMBIM famil...Continue Reading

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S Henikoff, J G Henikoff
Apr 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L WalterE Günther
Jul 20, 1995·Genomics·L WalterE Günther
Nov 1, 1996·European Journal of Biochemistry·M G Claros, P Vincens
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·N V SomiaI M Verma
Oct 18, 2000·Free Radical Biology & Medicine·B KadenbachE Bender
Nov 5, 2002·Brain Research. Molecular Brain Research·Beat SchweitzerVerdon Taylor
Apr 5, 2003·Science·Nicolas Demaurex, Clark Distelhorst
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Aug 12, 2004·Molecular Cell·Han-Jung ChaeJohn C Reed
Feb 9, 2005·Nucleic Acids Research·V A SimossisJ Heringa
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Béatrice Bailly-MaitreJohn C Reed
Apr 12, 2006·Genes & Genetic Systems·Hanjun ZhaoHiroshi Nojima
Jan 11, 2007·Journal of Microscopy·S Bolte, F P Cordelières
Apr 22, 2008·Nucleic Acids Research·A DereeperO Gascuel
Jun 26, 2009·Molecular Biology of the Cell·Fabrizio de MattiaFrank J M van Kuppeveld
Nov 26, 2010·Apoptosis : an International Journal on Programmed Cell Death·Sudhanshu ShuklaSrinivasa M Srinivasula
Jan 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arno ReichJörg B Schulz
Jun 15, 2011·Cell Calcium·Nadine HenkeAxel Methner
Oct 1, 2011·Nature Methods·Thomas Nordahl PetersenHenrik Nielsen
Dec 1, 2011·The Journal of Biological Chemistry·Geert BultynckAxel Methner
Aug 10, 2012·Cell Death & Disease·S KiviluotoG Bultynck
Jul 23, 2013·Cell Calcium·Santeri KiviluotoGeert Bultynck
Nov 12, 2013·Biochimica Et Biophysica Acta·Saverio MarchiPaolo Pinton
Apr 10, 2014·Cell and Tissue Research·Michael K E SchäferAxel Methner
Sep 18, 2014·Science Signaling·Geert BultynckAxel Methner

❮ Previous
Next ❯

Citations

Dec 17, 2019·The FEBS Journal·Cynthia LebeaupinBéatrice Bailly-Maitre
Mar 19, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Albert Garcia-Quintanilla, Domingo Miranzo-Navarro
Oct 23, 2018·Frontiers in Genetics·Tássia Mangetti GonçalvesLuiz Lehmann Coutinho
Dec 12, 2018·Proceedings of the National Academy of Sciences of the United States of America·Anna LuganiniGiorgio Gribaudo
May 18, 2019·Current Pharmaceutical Biotechnology·Bednarczyk MartynaJanikowska Grażyna
Aug 21, 2019·International Journal of Molecular Sciences·Víctor Jiménez-GonzálezAlbert García-Quintanilla
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Caroline Jeeyeon HongSeong-Woon Yu
Jul 8, 2016·Journal of Neurochemistry·Laura Planells-FerrerJoan X Comella
Jul 25, 2019·Cancers·Raghu Patil JunjappaHan-Jung Chae
Jan 17, 2020·In Vitro Cellular & Developmental Biology. Animal·Yubin PanYan Zhang
May 13, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Koenraad PhilippaertAxel Methner
May 5, 2017·Open Biology·Guia CarraraGeoffrey L Smith
Jan 28, 2021·Genes·Ilaria Pontisso, Laurent Combettes
Nov 20, 2020·Proceedings of the National Academy of Sciences of the United States of America·Chieh-Chin LiYun-Wei Chiang
Jan 9, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Qun Liu
Oct 22, 2017·Cell Calcium·Amado Carreras-SuredaClaudio Hetz
Apr 3, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Fernanda O LemosJan B Parys
Nov 13, 2021·Science Advances·Philippe PihánClaudio Hetz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.