Abstract
The poor prognosis, few available treatment options, and multidrug resistance present in hepatocellular carcinoma are major problems, and new early biomarkers are needed to reduce the liver cancer death rate. ATP-binding cassette sub-family C member 3 (Abcc3) is overexpressed in different cancers and is associated with multidrug resistance and a carcinogenic stem cell phenotype. We present evidence for the first time that ABCC3 is a potential sanguine biomarker and anticancer target in hepatocellular carcinoma. Abcc3 mRNA expression was elevated in liver nodules and tumors in rat hepatocarcinogenesis model. Accordingly, the ABCC3 protein was preferentially overexpressed within the nodules and tumors during hepatocellular carcinoma progression and was secreted into the bloodstream of rat hepatocarcinogenesis model. The ABCC3 protein was expressed in human hepatoma cells and, importantly, was also present in HepG2- and Huh7-conditioned media. Furthermore, ABCC3 was overexpressed in human hepatocellular carcinoma. This report is the first to describe liver overexpression of Abcc3 during the cancer initiation, promotion, and progression periods in rat hepatocarcinogenesis model and in human hepatocellular carcinoma.
References
Dec 4, 1992·Science·S P ColeR G Deeley
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·M KoolP Borst
Oct 9, 2001·The Journal of Biological Chemistry·A InokuchiT Uchiumi
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·A T NiesD Keppler
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ju-Seog LeeSnorri S Thorgeirsson
Jan 29, 2005·Carcinogenesis·Ju-Seog LeeSnorri S Thorgeirsson
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Jörg KönigDietrich Keppler
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zineb BenderraOllivier Legrand
May 23, 2006·Placenta·M A SerranoJ J G Marin
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hung HuynhEvelyn Tran
Jul 16, 2008·Journal of Hepatology·Eishiro MizukoshiShuichi Kaneko
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Florie BorelUNKNOWN Réseau Centre de Ressources Biologiques Foie (French Liver Biobanks Network), France
Feb 24, 2012·Radiology·Shanmugasundaram Ganapathy-KanniappanJean-François H Geschwind
Mar 1, 2012·Pathology International·Sang Hyub LeeHo-Seong Han
May 16, 2012·Genes, Chromosomes & Cancer·Laura PartanenJorma Isola
Nov 14, 2012·Nature Reviews. Gastroenterology & Hepatology·Augusto VillanuevaJosep M Llovet
Jan 4, 2013·PloS One·Samantha Wei-Man LunKwok-Wai Lo
Feb 27, 2013·Oncology·Chiao-Ling TsaiJason Chia-Hsien Cheng
Mar 23, 2013·Biomaterials·Xu MaWan-Liang Lu
Jun 13, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eun Ju ChoHyo-Suk Lee
Jul 16, 2013·Annals of Surgical Oncology·Tian YangFeng Shen
Nov 2, 2013·Scientific Reports·Yanbin ZhaoLi Cai
Feb 14, 2014·Leukemia Research·Mohammad Reza Noori-DaloiiAli Reza Noori-Daloii
Apr 12, 2014·Oncotarget·Kodappully Sivaraman SiveenGautam Sethi
Aug 12, 2014·PloS One·Yingqiang WangXianglian Li
Citations
Nov 2, 2017·Biology of Reproduction·Leonie R PriceGraham C Burdge
Jan 6, 2018·Current Medicinal Chemistry·María Paula CeballosMaría Laura Ruiz
Jul 8, 2016·Journal of Clinical Pharmacology·Amandla Atilano-RoqueMelanie S Joy
Jul 18, 2020·Toxicology Letters·Keith R ShockleyJune K Dunnick
Feb 15, 2021·Annals of Hepatology·Suilma Ivette Pérez-PinedaJosé Luis Rosales-Encina
Jan 28, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Melina M MalinenKim L R Brouwer
Mar 4, 2021·British Journal of Pharmacology·Aimo KanntDieter Schmoll