PMID: 8583382Sep 1, 1995Paper

The transmucosal absorption of recombinant human interferon-alpha B/D hybrid in the rat and rabbit

The Journal of Pharmacy and Pharmacology
D BayleyN Lowther

Abstract

For therapeutic proteins such as interferon-alpha B/D, a non-parenteral route of delivery is desirable. Possible sites of administration include the various regions of the gastrointestinal tract and airways, and this paper reports the bioavailability of interferon-alpha B/D via these routes in the rat and rabbit. Apart from the stomach, detectable levels of interferon-alpha B/D in the serum were achieved via all routes. Bioavailabilities were less than 1%, except from the lung (6.8% in the rat) and nasal cavity (2.9% in the rabbit). Absorption from the gastrointestinal tract was similar for both species, but in the nasal cavity of the rabbit was sixfold that of the rat, and in the lung of the rat was tenfold that in the rabbit. Absorption from all routes, except the buccal cavity, resulted in detectable biochemical changes in the liver of the rabbit. Comparison with reports from other groups show differences in the extent of absorption of interferon-alpha B/D and of natural or homologous recombinant interferon-alpha. The non-parenteral delivery of biochemically active amounts of interferon-alpha B/D is thus demonstrated.

References

Sep 1, 1992·Pharmaceutical Research·M E DowtyJ R Robinson
Apr 1, 1992·Journal of Interferon Research·H TowbinM A Horisberger
Aug 1, 1989·Journal of Interferon Research·V KinnulaK Cantell
Mar 1, 1987·The Journal of General Virology·M A Horisberger, K de Staritzky
Aug 1, 1993·Journal of Applied Physiology·O D WangensteenR C Maynard

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Citations

Jun 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Senel, A A Hincal
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M G ToveyC Maury
Jan 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T J Kaido
Jul 12, 2012·Drug Development and Industrial Pharmacy·Osamu Sakata, Hiraku Onishi
May 13, 2014·Expert Opinion on Drug Delivery·Alice L SmartAbdul W Basit
Mar 25, 2010·British Journal of Haematology·Claire N HarrisonUNKNOWN British Committee for Standards in Haematology
May 4, 2007·International Journal of Pharmaceutics·Henry R CostantinoSteven C Quay

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