PMID: 6672Feb 1, 1976

The transport of tetracyclines across the mouse ileum in vitro: the effect of cations and other agents

The Journal of Pharmacy and Pharmacology
S Banerjee, K Chakrabarti

Abstract

The intestinal transfer of different tetracyclines dissolved in calcium- and magnesium-free Krebs bicarbonate buffer solution, pH 7.4, was studied using the everted ileum of the mouse. The rates of transfer of chlortetracycline and demethylchlortetracycline were less than those of tetracycline and oxytetracycline, the latter compounds being transferred at the same rate. Addition of calcium and magnesium to the buffer greatly reduced the transfer of tetracycline; this inhibition could be antagonized by EDTA. The presence of iron also inhibited the transfer of tetracycline. The inhibitory effect of these ions on tetracycline transfer seemed due to chelation of the drug. Glucosamine and acetylmethionine, but not acetyl glucosamine, diminished the intestinal transfer of tetracyclines. The former two agents did not influence the uptake of tissue fluids. Tetracycline was also transfered from the serous to the mucous coat in the non-everted intestinal sac of mice. The above observations suggested that the absorption of tetracyclines was not due solely to passive diffusion.

References

Nov 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·M Gibaldi, B Grundhofer
Jul 15, 1972·Experientia·G TesoriereL Castagnetta
Oct 1, 1969·Journal of Pharmaceutical Sciences·J L Colaizzi, P R Klink
Feb 1, 1970·European Journal of Pharmacology·R R LevineR LeBlanc
May 1, 1971·Annals of Internal Medicine·N J Greenberger
Feb 1, 1971·Journal of Pharmaceutical Sciences·L Z BenetH S Webb

Citations

Feb 9, 2012·The Journal of Pharmacy and Pharmacology·Mohd Aftab AlamAbdullah M Al-Mohizea
Jan 31, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·H Poiger, C Schlatter
Apr 25, 2007·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Hila ShovalEhud Gazit
Aug 1, 1979·Australian and New Zealand Journal of Medicine·M F O'RourkeD Le Cheminant
Dec 1, 1977·The Journal of Pharmacy and Pharmacology·C Marriott, I W Kellaway

Related Concepts

Calcium
Xicil
Ileum
Intestinal Absorption
Iron
Magnesium
Pedameth
Tetracyclines

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