The transthyretin gene is expressed in human and rodent dorsal root ganglia

Neuroscience Letters
Tatsufumi MurakamiYoshihide Sunada

Abstract

The transthyretin (TTR) gene is mainly expressed in the liver and choroid plexus of the brain. Most cases of familial amyloidotic polyneuropathy (FAP) are caused by TTR gene mutations, and characterized by amyloid deposition in the peripheral nervous system. We hypothesized that the TTR gene may be expressed in the peripheral nervous system. We analyzed TTR gene expression in several parts of the human, mouse and rat peripheral nervous systems using RT-PCR. To determine the sites of TTR synthesis in the dorsal root ganglia (DRG), mouse DRG were examined by in situ hybridization, laser capture microdissection and RT-PCR, and immunohistochemistry. TTR mRNA was detected in the DRG and cauda equina of humans and rodents by RT-PCR. TTR mRNA was not detected in the sural nerve, lumbar plexus or sympathetic ganglia in humans, or in the sciatic nerve in rodents. In mouse DRG, TTR mRNA was localized in the peripheral glial cells. No TTR-like immunoreactivity was observed in these tissues except for the perineurium. The TTR gene is probably expressed in the peripheral glial cells of the DRG. TTR synthesis in the DRG may be important for the involvement of the peripheral nervous system in FAP.

References

Aug 1, 1990·Brain : a Journal of Neurology·G SobueA Takahashi
Jan 1, 1995·Pathology International·T MurakamiM Ando
Feb 21, 1998·Nucleic Acids Research·T HeinemeyerN A Kolchanov
Apr 12, 2005·Cell·Yoshiki SekijimaJeffery W Kelly
Apr 23, 2005·Cell and Tissue Research·H A MontecinosE M Rodríguez
Sep 2, 2005·Nature Reviews. Neuroscience·Kristjan R Jessen, Rhona Mirsky
May 16, 2006·Neurobiology of Aging·João Carlos SousaJoana Almeida Palha
Sep 28, 2007·Journal of Neurochemistry·Carolina E FlemingMónica M Sousa

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Citations

Oct 27, 2009·Neuroscience Letters·Johannes BrettschneiderHayrettin Tumani
Aug 12, 2009·Progress in Neurobiology·Carolina Estima FlemingMónica Mendes Sousa
Oct 7, 2008·Experimental Neurology·Mónica Mendes Sousa, Maria João Saraiva
Jun 16, 2010·Brain Research·Tatsufumi MurakamiYoshihide Sunada
Dec 19, 2014·Acta Neuropathologica Communications·Nádia P GonçalvesMaria J Saraiva
Feb 19, 2015·Journal of Neurochemistry·Tatsufumi MurakamiYoshihide Sunada
Feb 26, 2019·Journal of Clinical Neuromuscular Disease·George ZanazziKurenai Tanji
Aug 28, 2020·Journal of Neurochemistry·Tatsufumi MurakamiYoshihide Sunada
Mar 8, 2020·Scientific Reports·Bandar AlshehriSamantha J Richardson
Jul 24, 2021·Cellular and Molecular Life Sciences : CMLS·Joana MagalhãesMárcia Almeida Liz

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