The treatment efficacy of adding prokinetics to PPIs for gastroesophageal reflux disease: a meta-analysis

Esophagus : Official Journal of the Japan Esophageal Society
Liting XiAirong Wu

Abstract

Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder. Proton pump inhibitors (PPIs) are first-line drugs for GERD. For those who fail to respond to PPIs, adding prokinetics to PPIs is recommended and several trials have been conducted to evaluate the efficacy of prokinetic-PPI combination therapy. A systematic literature search was performed using PubMed and the Cochrane Library databases before February 2019 for randomized controlled trials (RCTs), which compared the efficacy of prokinetics plus PPI treatment with that of PPI monotherapy. Relevant studies were examined and data were extracted independently by two investigators. The risk ratios (RRs) with 95% CIs were used to evaluate the responder rate, and standard mean differences (SMDs) or mean differences (MDs) with 95% CIs were used for symptom score changes. Statistical heterogeneity was evaluated by the I2 statistic. Either a fixed-effect or a random-effect model was established for calculating the pooled data. A total of 14 studies, comprising 1,437 patients were ultimately included in the meta-analysis. The pooled analysis showed that compared to PPI monotherapy, addition of prokinetics to PPI did not elevate the rate of endoscopic responders (...Continue Reading

References

Aug 17, 2001·European Journal of Gastroenterology & Hepatology·C J van Rensburg, K D Bardhan
Dec 1, 2004·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·K MadanM P Sharma
Jul 14, 2005·Alimentary Pharmacology & Therapeutics·R FassJ Sewell
Aug 25, 2006·The American Journal of Gastroenterology·Nimish VakilUNKNOWN Global Consensus Group
Dec 13, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ian M GralnekBrennan M R Spiegel
Jul 27, 2010·British Journal of Clinical Pharmacology·Yao-Chun HsuHwai-Jeng Lin
Mar 25, 2011·Trends in Pharmacological Sciences·Tiberiu Hershcovici, Ronnie Fass
Jun 22, 2016·Journal of Gastroenterology·Katsuhiko IwakiriTooru Shimosegawa
Aug 7, 2017·Gastroenterology·Joel E Richter, Joel H Rubenstein
Aug 23, 2017·Gastroenterology·C Prakash Gyawali, Ronnie Fass
Nov 8, 2017·Digestive Diseases and Sciences·Yu-Min KungYao-Kuang Wang
Feb 14, 2018·Gut·C Prakash GyawaliSabine Roman
Apr 3, 2018·Clinical and Experimental Gastroenterology·Joseph MermelsteinMaxwell M Chait
May 16, 2018·Annals of the New York Academy of Sciences·C Prakash GyawaliJustin Wu

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Citations

Jun 10, 2021·Journal of Digestive Diseases·Ying Lian XiaoUNKNOWN Chinese Society of Gastroenterology

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