The treatment landscape in thyroid cancer: a focus on cabozantinib

Cancer Management and Research
Steven P Weitzman, Maria E Cabanillas

Abstract

Although patients with thyroid cancer generally fare well, there is a subset for which this is not necessarily true. Progress in understanding the molecular aberrations in thyroid cancer has led to a change in the management of these cases. Since 2011, four multikinase inhibitors (MKIs) have been approved by the US Food and Drug Administration for thyroid cancer - cabozantinib and vandetanib for medullary thyroid cancer and sorafenib and lenvatinib for differentiated thyroid cancer. This change in the treatment landscape has raised challenges for practitioners who may not be familiar with the use of MKIs or with the treatment and natural history of advanced thyroid cancer in general. This article reviews the epidemiology, molecular drivers, and initial treatment of patients with thyroid cancer and offers practical guidance to assist with the determination of when to appropriately start an MKI. As an example, cabozantinib and its efficacy are discussed in detail. Close monitoring is required for all patients on targeted agents to assess for adverse effects and response to therapy. An approach to managing drug-related adverse events is detailed. Since these drugs are not curative and have not yet proven to prolong overall surviva...Continue Reading

Citations

Mar 17, 2017·Frontiers in Oncology·Makoto TaharaShunji Takahashi
Aug 3, 2021·Frontiers in Endocrinology·Tanner FullmerMark Zafereo
Nov 12, 2019·International Journal of Clinical Endocrinology and Metabolism·Apoorva JayarangaiahSamy I McFarlane

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BETA
Transfection
dissection

Clinical Trials Mentioned

NCT02041260
NCT01811212
NCT02034110
NCT01236547
NCT01896479

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