PMID: 11829858Feb 7, 2002Paper

The treatment of 432 patients with pituitary adenomas via transsphenoidal approach

Zhonghua wai ke za zhi [Chinese journal of surgery]
Z WuX Shao


To study some clinical features of 432 cases of pituitary adenomas treated by transsphenoidal microsurgery between July 1982 and October 1996. Pathological examination, immunohistochemical examination and electronmicroscopic examination were done in 424, 29 and 103 cases respectively. Hyperprolactinemia was found in many so-called non-functioning adenomas besides in prolactinomas. The dura maters were invaded by tumors in 78 cases (the incidence of dural invasion was 65.5%). Hyperprolactinemia is not peculiar to prolactinomas, and differential diagnosis is necessary when hyperprolactinemia exists. The involvement of the dura mater of sellar floor is an important mark that the adjacent tissues were invaded by pituitary adenomas. The outcome of surgical treatment is significantly different between the patients with dural invasion and without invasion.

Related Concepts

Adenoma, Trabecular
Neoplasm Invasiveness
Pituitary Carcinoma
Retrospective Studies

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