The treatment of atrophic, recalcitrant long-bone nonunion in the upper extremity with human recombinant bone morphogenetic protein-7 (rhBMP-7) and plate fixation: A retrospective review

Injury
Zachary MorisonMichael D McKee

Abstract

Recombinant Human Bone Morphogenetic Protein-7 (rhBMP-7) has been shown to promote fracture healing in both clinical studies and basic science models, however, there is little information from large-scale studies of its use for human nonunion. The purpose of this study was to determine the safety and efficacy of rhBMP-7 in the treatment of atrophic human long-bone nonunions in the upper extremity. This was a single center, retrospective, longitudinal cohort study of patients treated with compression plating and the application of rhBMP-7 in isolation to a long-bone nonunion. Patients over sixteen years of age with an atrophic, aseptic nonunion of a humerus, radius, ulna or clavicle were eligible for inclusion. We identified seventy eligible patients who were treated with rhBMP-7 for a long-bone nonunion between July 1997 and April 2012. The mean age of the patients at the time of treatment with rhBMP-7 was 50.7 years (range, 20-92 years). Five patients were lost to follow-up prior to definitive clinical or radiographic union. During the one-year post-operative period fifty-six patients had achieved union and two patients developed a stable fibrous union after the index procedure. Two patients had early implant failure and five ...Continue Reading

References

Sep 29, 2005·Injury·Pietro De Biase, Rodolfo Capanna
Oct 27, 2007·International Orthopaedics·Andrew P WhiteMichael D McKee
Nov 17, 2009·Cytokine & Growth Factor Reviews·Moulay Hicham Alaoui-Ismaili, Dean Falb
Feb 13, 2013·Injury·Taco J BlokhuisGerhard Schmidmaier
Feb 16, 2013·Journal of Orthopaedic Trauma·Louis F AmorosaDavid L Helfet

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Citations

Jan 3, 2020·The Journal of Bone and Joint Surgery. American Volume·Donald A Wiss, John M Garlich
Jul 15, 2020·Journal of Shoulder and Elbow Surgery·Donald A Wiss, John M Garlich
Apr 2, 2021·Hand : Official Journal of the American Association for Hand Surgery·Alexis B SandlerJohn C Dunn

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