PMID: 9189179Jan 1, 1997Paper

The treatment of disseminated malignant melanoma with special reference to the role of interferons, vinca alkaloids and tamoxifen

Cancer Treatment Reviews
W R Bezwoda

Abstract

Malignant melanoma continues to increase in incidence. While early melanoma is highly curable by surgical means, the prognosis of patients with more advanced lesions and/or metastatic disease remains poor. Conventional chemotherapy with dacarbazine has a low frequency and short duration of response. Alternative drugs with single-agent activity include vinca alkaloids, nitrosoureas, procarbazine and platinum compounds. The addition of tamoxifen to chemotherapy, particularly cisplatin-based chemotherapy, appears to be beneficial. Recent studies suggest that combination chemotherapy may give better outcomes than single-agent treatment. Significant clinical activity has also been demonstrated with the use of interferons, particularly interferon alpha, and also with IL-2. Two recent studies suggest that the addition of interferon to chemotherapy may be beneficial. In addition, specific active immunotherapy with tumour vaccines has shown promise. The optimal methods of combining these treatment methods, such as chemotherapy and biological response modifiers/immunotherapy, however, remain to be defined.

References

Jan 1, 1979·Cancer Chemotherapy and Pharmacology·S RetsasG Westbury
Aug 20, 1992·The New England Journal of Medicine·G CocconiP Costa
Feb 1, 1991·Investigational New Drugs·A I EinzigT J Smith
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S Gundersen, A Flokkmann
Mar 15, 1991·Cancer·J W Yarbro
Jul 15, 1987·International Journal of Cancer. Journal International Du Cancer·W Popik, A D Inglot
Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·S OsantoF J Cleton
Feb 14, 1985·Nature·M Clemens
Jan 1, 1988·Pharmacology & Therapeutics·L E Damon, E C Cadman
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·U Elsässer-BeileE Schöpf
Dec 24, 1981·Nature·A A Branca, C Baglioni
Jan 1, 1984·Pharmacology & Therapeutics·G C Sen
Dec 1, 1982·European Journal of Cancer & Clinical Oncology·J CarmichaelJ F Smyth
Dec 1, 1982·European Journal of Cancer & Clinical Oncology·J H MulderM Rozencweig
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B Gansbacher
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G J NabelA E Chang
Aug 12, 1993·Annals of the New York Academy of Sciences·P Hersey
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E E MedranoJ J Nordlund

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Citations

Sep 2, 1999·Biochemical and Biophysical Research Communications·M TorciaF Cozzolino
Jun 6, 2000·Plastic and Reconstructive Surgery·W K StadelmannD S Reintgen
Jul 10, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J-C de VicenteM-F Fresno
Mar 27, 2001·Japanese Journal of Cancer Research : Gann·M MiharaD T Wong
Jun 20, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Soo Hyung RyuDong Jin Suh
May 11, 2011·Immunotherapy·Pierre L TriozziErnest Borden
Mar 19, 2004·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Binglan Yu, Thomas Ming Swi Chang

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