PMID: 322491Apr 15, 1977Paper

The treatment of dysmenorrhea with naproxen sodium: a report on two independent double-blind trials

American Journal of Obstetrics and Gynecology
M R HenzlS Bessler


The efficacy of naproxen sodium (naproxen-Na) in dysmenorrhea has been established in two independent double-blind (placebo-controlled) studies. An initial dose of 550 mg. of naproxen-Na was followed by 275 mg. every six hours for a maximum of five days. Twenty patients were included in Study I (10 treated with naproxen-Na) and 23 patients in Study II (12 treated with naproxen-Na). Each patient received the medication during four dysmenorrheic episodes. Thus, a total of 172 treatment courses could be evaluated. A variety of efficacy criteria were measured: frequency of pill intake, changes in pain intensity, the degree of relief achieved by the medication, and need for additional analgesics. In both studies naproxen-Na was demonstrated to be superior to the placebo treatment with high statistical significance in each of these parameters.


Jan 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·G A Kintis, B Coutifaris
Jan 1, 1984·Drug Intelligence & Clinical Pharmacy·N J Wenzloff, L Shimp
Apr 1, 1980·British Journal of Obstetrics and Gynaecology·J R Pogmore, G M Filshie
Jun 1, 1980·British Journal of Clinical Pharmacology·U R KrishnaU K Sheth
Aug 1, 1979·British Journal of Obstetrics and Gynaecology·M G Elder, L Kapadia
Nov 1, 1979·The Australian & New Zealand Journal of Obstetrics & Gynaecology·C WoodR Williams
Feb 1, 1978·British Journal of Obstetrics and Gynaecology·K E Andersson, U Ulmsten
Dec 18, 1978·European Journal of Clinical Pharmacology·T JanbuB I Nesheim
Nov 1, 1984·British Journal of Obstetrics and Gynaecology·I Milsom, B Andersch
Jan 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A J Davies
Aug 6, 1998·British Journal of Obstetrics and Gynaecology·W Y Zhang, A Li Wan Po
Jul 2, 2015·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Omid R ZekavatFarzaneh Alipour
Aug 1, 1979·Archives of Gynecology·B SandahlK E Andersson
Jan 1, 1978·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H A SandeA Izu
Feb 22, 1978·Archiv für Gynäkologie·P Kajanoja
Aug 1, 2015·The Cochrane Database of Systematic Reviews·Jane MarjoribanksMichelle Proctor
Feb 1, 1981·Prostaglandins and Medicine·O YlikorkalaA Kauppila

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