PMID: 9550589Apr 29, 1998Paper

The treatment of heart failure: the role of neurohumoral activation

Internal Medicine
H R Middlekauff, A L Mark

Abstract

Neurohumoral activation refers to increased activity of the sympathetic nervous system, renin-angiotensin system, vasopressin and atrial natriuretic peptide. It is now known that neurohumoral activation contributes to the transition from ventricular dysfunction to clinical heart failure, and is an independent predictor of poor prognosis in heart failure. Although the treatment of heart failure has traditionally focused on drugs to improve ventricular function, there is increasing evidence that therapeutic modulation of neurohumoral activation is a key to successful treatment of heart failure. For example, there is mounting evidence that angiotensin converting enzyme inhibitors (the unquestioned cornerstone for treatment of heart failure), beta receptor blockers, digitalis, and endurance exercise training exert their benefit in heart failure in large part through neurohumoral modulation. This observation--discussed in this brief review--highlights the concept that compensatory neurohumoral activation to decreased cardiac function may itself contribute to the development of heart failure and its poor prognosis.

Citations

Jul 3, 2013·Current Treatment Options in Cardiovascular Medicine·Khanjan B ShahRebecca S Boxer
Aug 14, 1999·Progress in Biophysics and Molecular Biology·Y Shimoni
Sep 6, 2003·Journal of the American College of Cardiology·Fabiana RovedaCarlos Eduardo Negrão
Dec 30, 1999·Journal of Endocrinological Investigation·S SavastanoG Lombardi
Sep 3, 2008·Autonomic Neuroscience : Basic & Clinical·Koji ItoKenji Sunagawa
Oct 10, 2012·Seminars in Dialysis·Joselyn Reyes-BahamondePeter Kotanko
Oct 26, 2011·Journal of the American Academy of Nurse Practitioners·Lisa C BauerBunny J Pozehl
Jan 3, 2006·Annals of Emergency Medicine·W Frank PeacockCharles Emerman
Aug 18, 2005·Journal of Cardiac Failure·Varda KonstamMarla J De Jong
Feb 5, 2013·Autonomic Neuroscience : Basic & Clinical·J E Stern, J A Filosa
May 1, 2009·Autonomic Neuroscience : Basic & Clinical·Eleonora TobaldiniNicola Montano
Jun 21, 2016·Canadian Journal of Physiology and Pharmacology·Péter NánásiZoltán Papp
Oct 16, 2016·Heart·Athar Ali Tajik, Kenneth Dickstein
Feb 10, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J F CarrollJ S Cohen
Oct 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Joseph FrancisRobert B Felder
Feb 19, 1999·Circulation Research·H HupfH Schunkert
Jan 1, 2016·Journal of Biomechanical Engineering·Stephen P Ma, Gordana Vunjak-Novakovic
Jul 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Koji SakaiKenji Sunagawa
Jan 10, 2014·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Cristina ZarboClaudia Romagnoni
Jan 31, 2002·Psychosomatic Medicine·Setareh A WilliamsViola Vaccarino
Sep 3, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Holly R MiddlekauffJeffrey A Gornbein
May 23, 2002·Journal of Hypertension·Hans Peter Brunner-La RoccaMurray D Esler
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H ShigematsuA Takeshita
Dec 19, 2002·Drugs·Gillian M Keating, Karen L Goa
Mar 4, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Luyao MaShijiang Zhang
Jan 17, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert B FelderAlan Kim Johnson
Oct 2, 2002·European Journal of Biochemistry·Nduna Dzimiri
Nov 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Kaushik P Patel, Hong Zheng
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J FrancisR B Felder
Jul 28, 2019·Respiratory Medicine·Linn E MooreMichael K Stickland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
F Zijlstra
The Journal of Cardiovascular Nursing
Anne E StecklerInder S Anand
Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association
Richard J ContradaTyrone J Krause
© 2022 Meta ULC. All rights reserved