PMID: 11329820May 2, 2001Paper

The treatment of hypertension in patients with erectile dysfunction

Current Medical Research and Opinion
D P MikhailidisR J Morgan

Abstract

Hypertension is another predictor of erectile dysfunction (ED). This is further evidence supporting a link between the pathogenesis of atherosclerotic disease and ED. In one study (TOMHS) involving hypertensive patients, the incidence of ED was 14.4%. The drugs used to treat hypertension may cause ED. However, there is little trial-based evidence to indicate which drugs are more likely to cause this side effect. In general, thiazide diuretics and beta-blockers seem to cause ED more often. In contrast, the alpha-blocker, doxazosin, has not been associated with an increased incidence of ED as a side effect. Doxazosin also improves urinary flow in patients with benign prostatic hyperplasia (BPH). This condition is common in elderly men as is hypertension and ED. Therefore, doxazosin may present a special advantage among this group of patients. This alpha-blocker would also be a good choice in patients with impaired glucose tolerance/diabetes because it improves insulin sensitivity. Moreover, ED and hypertension are more prevalent among diabetics. On a more speculative note, doxazosin may potentiate the therapeutic impact of specific treatments for ED.

References

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Citations

May 10, 2002·Current Medical Research and Opinion·M A KhanUNKNOWN Consensus Writing Committee
May 2, 2001·Current Medical Research and Opinion·A Ledda
Jun 17, 2011·The Journal of Sexual Medicine·Markos KaravitakisGrigorios Doumanis
Jul 24, 2010·The Journal of Sexual Medicine·Jae-Seung PaickDae Yul Yang
Jun 9, 2011·The Journal of Clinical Hypertension·Joel Handler
May 23, 2002·Current Medical Research and Opinion·Masood A KhanDimitri P Mikhailidis
Jul 5, 2003·Current Medical Research and Opinion·Andrea SaloniaFrancesco Montorsi
Jan 31, 2006·Angiology·Athanasios G Papatsoris, Panagiotis G Korantzopoulos
Apr 5, 2003·Acta Neurologica Scandinavica·D W DrosteE B Ringelstein
Apr 1, 2004·Journal of Endocrinological Investigation·C ForestaM Rossato
May 8, 2004·Journal of Endocrinological Investigation·A AversaG Spera
Jan 16, 2016·Clinical and Molecular Hepatology·Min KimByung Seok Lee
Oct 28, 2004·Pharmacoepidemiology and Drug Safety·K B Yusuff, O B Balogun

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