PMID: 6540691Aug 1, 1984Paper

The treatment of intravenously implanted Lewis lung carcinoma with two sustained release forms of 1-beta-D-arabinofuranosylcytosine

European Journal of Cancer & Clinical Oncology
Y E RahmanM MacCoss

Abstract

Liposomes have been used in recent years as carriers for drugs and molecules of biological importance. In cancer chemotherapy, however, the advantages of liposome encapsulation of antitumor drugs remain uncertain, with the possible exception of the usefulness of encapsulated 1-beta-D-arabinofuranosyl-cytosine (ara-C), an antitumor drug of a very short half-life. Liposome-encapsulated ara-C has been shown by others to enhance significantly the survival time of mice bearing leukemia, and the enhancement may be attributable to the role of liposomes as a slow release system for ara-C. We now further explore the advantages of two sustained release systems for ara-C, namely the liposome-encapsulated ara-C and 1-beta-D-arabinofuranosylcytosine-5'-diphosphate-L-1,2-dipalmitin (ara-CDP-L-dipalmitin, a prodrug of ara-C). Intravenously implanted Lewis lung carcinoma is used as a solid tumor model. The therapeutic effectiveness of the two slow release forms of ara-C given by either i.v. or i.p. injections is examined. Viable tumor cells (1.0 X 10(5) cells/mouse) were inoculated i.v. and treatment was initiated 24 hr later using three schedules of multiple treatments for liposomal ara-C and single or multiple injections of ara-CDP-L-dipalmi...Continue Reading

Citations

Jun 1, 1987·Cancer Treatment Reviews·N Willmott
Aug 9, 2005·Biochimica Et Biophysica Acta·Pierre SimardJean-Christophe Leroux
Sep 15, 1984·International Journal of Cancer. Journal International Du Cancer·K R Patel, J D Baldeschwieler
May 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A UchidaK Ono
Aug 7, 2002·Clinical Pharmacokinetics·Akinobu HamadaMasahiro Nakano
Jan 15, 1986·International Journal of Cancer. Journal International Du Cancer·W RubasR Schwendener
May 28, 1992·International Journal of Cancer. Journal International Du Cancer·R A Schwendener, H Schott

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