PMID: 6406688Jun 1, 1983Paper

The treatment of metastatic prostatic cancer with a potent luteinizing hormone releasing hormone analogue

The Journal of Urology
J Trachtenberg

Abstract

Metastatic prostatic cancer generally is treated by either castration or the administration of exogenous estrogens, both of which have significant clinical disadvantages. Luteinizing hormone releasing hormone analogues have been shown to suppress gonadal steroidogenesis in animals and humans. To assess the effect of the administration of a potent luteinizing hormone releasing hormone analogue, (D-Leu-6)luteinizing hormone releasing hormone (1-9) nonapeptide ethylamide, 9 patients with previously untreated stage D2 prostatic cancer were treated with this agent for 3 to 8 months. By 3 months of treatment all patients demonstrated a significant decrease in serum testosterone and a decreased peak serum luteinizing hormone and testosterone response to the acute administration of the analogue, with no change in baseline serum luteinizing hormone or prolactin. These data suggest that this analogue acts by decreasing the pituitary release of luteinizing hormone. No major adverse effects were noted with this treatment modality, and all patients were symptomatically improved and demonstrated a decrease or stabilization in tumor activity as measured by prostatic computerized tomography or ultrasound scan, prostatic acid phosphatase and bo...Continue Reading

Citations

Jan 1, 1985·The Prostate·D Gonzalez-BarcenaA V Schally
Sep 5, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A L PotoskyR M Hoffman
Jul 2, 2003·Hospital Medicine·Raj Persad
Oct 1, 1985·Journal of the Royal Society of Medicine·G Williams
Jan 1, 1988·Pharmacology & Therapeutics·S P Robinson, V C Jordan
Aug 25, 1984·Lancet·J Trachtenberg, A Pont
Nov 1, 1988·Current Problems in Cancer·F S FreihaF M Torti

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