PMID: 9635697Jul 4, 1998Paper

The treatment of nonpalpable PSA-detected adenocarcinoma of the prostate with 3-dimensional conformal radiation therapy

International Journal of Radiation Oncology, Biology, Physics
Eric M HorwitzG E Hanks

Abstract

We reviewed our institution's experience treating patients with nonpalpable PSA-detected prostate cancer with three-dimensional conformal radiation therapy (3DCRT) to determine prognostic factors that predict for biochemical-free survival (bNED) control and present the bNED control rates. Between May 1, 1990 and November 30, 1994, 160 patients with nonpalpable PSA-detected prostate cancer received 3DCRT at Fox Chase Cancer Center (median total dose 73 Gy; range: 67-78 Gy). bNED failure was defined as three consecutive increases in posttreatment PSA after achieving a nadir. bNED failure was recorded as the time midway between the nadir and the first consecutive rising PSA. Five-year actuarial rates of bNED control were calculated for pretreatment PSA (0-9.9 vs. 10-19.9 vs. > or = 20 ng/ml), Gleason score (2-6 vs. 7-10), treatment field size (prostate vs. small pelvis), age (<65 vs. > or = 65), and dose (< or = 73 vs. >73 Gy) using Kaplan-Meier methods and compared using the Log rank test. The Cox model was used to multivariately establish independent predictors based on significant univariate factors. Median follow-up was 39 months (range: 2-84 months). The 5-year actuarial rate of bNED control was 86% for the entire group of pa...Continue Reading

References

Oct 1, 1996·International Journal of Radiation Oncology, Biology, Physics·E M HorwitzA A Martinez
Jan 1, 1997·International Journal of Radiation Oncology, Biology, Physics·T E SchultheissG E Hanks

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Citations

Sep 21, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Joost J NuyttensAndrew T Turrisi
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·G O De MeerleerW De Neve
Apr 27, 2005·International Journal of Radiation Oncology, Biology, Physics·David E MorrisJoel E Tepper
Dec 18, 2007·Seminars in Radiation Oncology·Daniel E Soto, Patrick W McLaughlin

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