The treatment of patients with elderly-onset rheumatoid arthritis at Niigata Rheumatic Center

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
Chinatsu TakaiKiyoshi Nakazono

Abstract

To investigate the clinical course of patients with elderly-onset rheumatoid arthritis (RA). We compared the characteristics, and clinical course of 55 patients who developed RA at over 80 years of age (elderly-onset [EO] group) with 119 patients who developed RA at 40-59 years of age (non-elderly onset [non-EO] group). We also investigated the characteristics and clinical course of 19 patients who developed RA at over 80 and who received biological disease-modifying anti-rheumatic drugs (bDMARDs). The mean DAS28-ESR (DAS) and HAQ-DI (HAQ) of the EO were significantly higher in comparison to the non-EO group (4.91±1.31 vs 4.41±1.47, p=0.043, 1.2±0.9 vs 0.5±0.6, p<0.01). For the first treatment, 87.3% in the EO group received conventional synthetic DMARDs (csDMARDs), none received MTX. The rate of prednisolone (PSL) administration in the EO group was significantly higher than the non-EO group (56.4% vs 30.3%, p<0.01). The DAS and HAQ were significantly decreased in both groups, while the HAQ of the EO group was higher than the non-EO group. The decrease in DAS and HAQ of the PSL users was significantly greater than the non-PSL users (ΔDAS: 2.55±1.83 vs 1.83±1.23, p<0.01, ΔHAQ: 0.9±1.0 vs 0.3±0.6, p=0.027). Among the 19 patients ...Continue Reading

References

Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman
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May 2, 2007·Arthritis and Rheumatism·Stéphane GenevayUNKNOWN Physicians of the Swiss Clinical Quality Management Program for Rheumatoid Arthritis
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Mar 7, 2012·Annals of Internal Medicine·Marije F BakkerUNKNOWN Utrecht Rheumatoid Arthritis Cohort Study Group
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Jul 27, 2012·Arthritis Care & Research·Jessica WiddifieldClaire Bombardier
Feb 17, 2017·International Journal of Rheumatic Diseases·Eri KatoShigeto Tohma

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