The treatment of postprandial hypotension in autonomic failure with 3,4-DL-threo-dihydroxyphenylserine

Neurology
R FreemanL Lipsitz

Abstract

Postprandial hypotension occurs commonly in patients with autonomic failure and may be due to attenuation of the normal sympathetic nervous system activation in response to meal ingestion. In a randomized, double-blind, placebo-controlled study, we investigated the therapeutic effect of the norepinephrine precursor 3,4-DL-threo-dihydroxyphenylserine (DL-DOPS) on this condition. We measured blood pressure, heart rate, forearm vascular resistance, and plasma DL-DOPS and norepinephrine in 11 patients with autonomic failure. DL-DOPS attenuated the postprandial fall in blood pressure. This was associated with an increase in plasma norepinephrine and forearm vascular resistance. DL-DOPS therapy did not change the postprandial increase in heart rate. There was a trend toward increased supine hypertension associated with DL-DOPS treatment. This study shows that DL-DOPS is a promising treatment for postprandial hypotension and provides support for the hypothesis that postprandial hypotension is, at least in part, due to decreased activation of the sympathetic nervous system.

Citations

Nov 28, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J E Morley
May 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·H Kaufmann
Mar 12, 1999·Annual Review of Medicine·C J Mathias, J R Kimber
Mar 19, 2014·Journal of the American Medical Directors Association·Laurence G TrahairKaren L Jones
Sep 2, 1998·Current Opinion in Neurology·H Kaufmann
Feb 13, 2009·Expert Review of Neurotherapeutics·Yvette A M GrimbergenBastiaan R Bloem
Jun 21, 2015·Expert Review of Cardiovascular Therapy·Horacio KaufmannJose-Alberto Palma
Jan 12, 2007·Cardiovascular Drug Reviews·David S Goldstein
Mar 19, 2014·Journal of the American Geriatrics Society·Alice C L OngJohn F Potter
Jun 15, 2011·Pharmacology & Therapeutics·Cyndya ShibaoItalo Biaggioni
May 8, 2015·Drugs & Aging·Kannayiram Alagiakrishnan
May 4, 2016·Current Treatment Options in Neurology·Dong In Sinn, Christopher H Gibbons
Jul 30, 2003·Circulation·Horacio KaufmannRoy Freeman
Feb 8, 2019·Expert Opinion on Pharmacotherapy·Santiago Pérez-LloretOlivier Rascol

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.